I was surprised to see that the authors detected between 60-70% vascularized area in the infarct border zone in the treated groups. These levels are more compatible with the levels found in the scar tissue rather than in bordering viable myocardium. It would have been interesting to see their histological sections to understand how far from the scar tissue they analyzed "border zone" angiogenesis. Further, details on fibrosis levels in the border zone rather than in the infarct may have been interesting. As the authors state that the morphology of their myoblasts changed with HGF overexpression, perhaps the stability of the myoblasts sheets with HGF were not as great as the ones without hHGF, which could contribute to the lack of apparent synergy on morphological and functional parameters?
