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closepepsin not papain
Posted by hooperjw on 15 May 2012 at 01:51 GMT
For example, the FDA recently approved Anascorp, a papain-treated polyclonal antibody F(ab′)2 against scorpion toxin produced in horses [14], [16].
http://plosone.org/article/info:doi/10.1371/journal.pone.0035996#article1.body1.sec4.p2
For example, the FDA recently approved Anascorp, a pepsin-treated polyclonal
antibody F(ab')2 against scorpion toxin produced in horses (Boyer LV,
Theodorou AA, Berg RA, Mallie J. Antivenom for Critically Ill Children with
Neurotoxicity from Scorpion Stings. N Engl J Med, 2009;360:2090-8). CroFab,
another FDA approved treatment, is a papain-treated polyclonal antibody Fab
against rattlesnake venom produced in sheep (Consroe P, Egen NB, Russell FE,
Gerrish K, Smith DC, Sidki A, et al. Comparison of a new ovine antigen
binding fragment (Fab) antivenin for United States Crotalidae with the
commercial antivenin for protection against venominduced lethality in mice.
J Trop Med Hyg 1995; 53(5):507510).