A Conserved MicroRNA Regulatory Circuit Is Differentially Controlled during Limb/Appendage Regeneration

Benjamin L. King; Viravuth P. Yin

doi:10.1371/journal.pone.0157106

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Peer-reviewed

Research Article

A Conserved MicroRNA Regulatory Circuit Is Differentially Controlled during Limb/Appendage Regeneration

Benjamin L. King,

Affiliations Kathryn W. Davis Center for Regenerative Biology and Medicine, Mount Desert Island, Biological Laboratory, Salisbury Cove, Maine, United States of America, Graduate School of Biomedical Science and Engineering, University of Maine, Orono, Maine, United States of America
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Viravuth P. Yin

* E-mail: vyin@mdibl.org

Affiliations Kathryn W. Davis Center for Regenerative Biology and Medicine, Mount Desert Island, Biological Laboratory, Salisbury Cove, Maine, United States of America, Graduate School of Biomedical Science and Engineering, University of Maine, Orono, Maine, United States of America
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A Conserved MicroRNA Regulatory Circuit Is Differentially Controlled during Limb/Appendage Regeneration

Benjamin L. King,
Viravuth P. Yin

Published: June 29, 2016
https://doi.org/10.1371/journal.pone.0157106

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The idea of dedifferentiation

Posted by eallen459 on 24 Feb 2018 at 10:32 GMT

I am a student in North London, and I am writing an article for my school artificial biological limbs. I was hoping you may be able to answer a few of my queries:
What could allow humans to regrow limbs like the axolotl, or to form dedifferentiated tissue if regenerative abilities in these animals are rooted in a common ancestor? Would it require genetic manipulation?
Would it also be possible to produce the limb apart from the body and then transplant it?

No competing interests declared.

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A Conserved MicroRNA Regulatory Circuit Is Differentially Controlled during Limb/Appendage Regeneration

A Conserved MicroRNA Regulatory Circuit Is Differentially Controlled during Limb/Appendage Regeneration

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The idea of dedifferentiation

Posted by eallen459 on 24 Feb 2018 at 10:32 GMT