Reader Comments

Post a new comment on this article

Can this become a general tool for quality assessment of sequence alignments?

Posted by Gerber on 14 Jan 2007 at 20:44 GMT

This paper demonstrates a simple and robust tool for alignment-independent quality assessment of sequence alignments. This especially comes in handy when large datasets are used (e.g. whole proteome alignments), since curating the data by hand is impossible.

Since there are many sequence-motifs out there it would be interesting to see if other motifs give similar results to the signal peptide. If they do, using other motifs in parallel to the signal peptide may allow decreasing the STD for small size scaling subgroup. Thus, the accuracy and usefulness of this tool would be extended.

report a concern respond to this posting