Control of Canalization and Evolvability by Hsp90

Claire C. Milton; Christina M. Ulane; Suzannah Rutherford

doi:10.1371/journal.pone.0000075

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Peer-reviewed

Research Article

Control of Canalization and Evolvability by Hsp90

Claire C. Milton,

Current address: Department of Biology, University College London, London, United Kingdom

Affiliation Center for Environmental Stress and Adaptation Research, University of Melbourne, Melbourne, Australia
⨯
Christina M. Ulane,

Current address: Medical Scientist Training Program, Mount Sinai School of Medicine, New York University School of Medicine, New York, New York, United States of America

Affiliations Center for Environmental Stress and Adaptation Research, University of Melbourne, Melbourne, Australia, Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Suzannah Rutherford

*To whom correspondence should be addressed. E-mail: srutherf@fhcrc.org

Affiliation Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯

Control of Canalization and Evolvability by Hsp90

Claire C. Milton,
Christina M. Ulane,
Suzannah Rutherford

Published: December 20, 2006
https://doi.org/10.1371/journal.pone.0000075

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see Methods

Posted by Suzannah on 26 Dec 2006 at 19:53 GMT

To compare unseen distributions of continuous variation in the strength of SC bristle signaling in Hsp90 mutant and wild-type populations of RI line genotypes, we modeled SC as a classical threshold trait. Using the observed frequencies of flies with abnormal SC bristle numbers (SC = 2, 3, 5) in P582i mutant and Sami populations and a set of simple assumptions consistent with Hsp90 biochemistry and current understanding of bristle development, we determined inferred distributions of liability for abnormal SC numbers in each population.
http://plosone.org/article/info:doi/10.1371/journal.pone.0000075#article1.body1.sec2.sec5.p2

A detailed description of the assumptions of this model is provided in the methods.

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Control of Canalization and Evolvability by Hsp90

Control of Canalization and Evolvability by Hsp90

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see Methods

Posted by Suzannah on 26 Dec 2006 at 19:53 GMT