Nomograms for Predicting the Prognostic Value of Pre-Therapeutic CA15-3 and CEA Serum Levels in TNBC Patients

Danian Dai; Bo Chen; Hailin Tang; Bin Wang; Zhiping Zhao; Xiaoming Xie; Weidong Wei

doi:10.1371/journal.pone.0161902

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Research Article

Nomograms for Predicting the Prognostic Value of Pre-Therapeutic CA15-3 and CEA Serum Levels in TNBC Patients

Danian Dai ,

Contributed equally to this work with: Danian Dai, Bo Chen, Hailin Tang

Affiliation Department of Breast Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
⨯
Bo Chen ,

Contributed equally to this work with: Danian Dai, Bo Chen, Hailin Tang

Affiliation Department of Breast Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
⨯
Hailin Tang ,

Contributed equally to this work with: Danian Dai, Bo Chen, Hailin Tang

Affiliation Department of Breast Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
⨯
Bin Wang ,

¶‡ These authors also contributed equally to this work.

Affiliation Institute of Life Science, Chongqing Medical University, Chongqing, China
⨯
Zhiping Zhao ,

¶‡ These authors also contributed equally to this work.

Affiliation Institute of Hepatopancreatobiliary Surgery, Southwest Hospital, Third Military Medical University, Chongqing, China
⨯
Xiaoming Xie ,

* E-mail: weiwd@sysucc.org.cn (WW); xiexm@sysucc.org.cn (XX)

Affiliation Department of Breast Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
⨯
Weidong Wei

* E-mail: weiwd@sysucc.org.cn (WW); xiexm@sysucc.org.cn (XX)

Current address: Department of Breast Oncology, Sun Yat-Sen University Cancer Center, 651 East Dongfeng Road, Guangzhou, 510060, China

Affiliation Department of Breast Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
⨯

Nomograms for Predicting the Prognostic Value of Pre-Therapeutic CA15-3 and CEA Serum Levels in TNBC Patients

Danian Dai,
Bo Chen,
Hailin Tang,
Bin Wang,
Zhiping Zhao,
Xiaoming Xie,
Weidong Wei

Published: August 25, 2016
https://doi.org/10.1371/journal.pone.0161902

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Subclasses of TNBC and serum CA 15-3 and CEA levels

Posted by kaltundag on 01 Sep 2016 at 20:22 GMT

I read with great interest the article by Dai et al addressing Nomograms for Predicting the Prognostic Value of Pre-Therapeutic CA15-3 and CEA Serum Levels in TNBC Patients.Multivariate analysis suggested that pre-therapeutic CA15-3 and CEA levels are independent predictive elements for OS (p = 0.022 and p = 0.040, respectively) and DFS (p = 0.023 and p = 0.028, respectively). In discussion part, they did not mention a probable association between subclasses of TNBC and serum CA 15-3 and CEA levels. As we know that Cluster analysis identified 6 TNBC subtypes displaying unique GE and ontologies, including 2 basal-like (BL1 and BL2), an immunomodulatory (IM), a mesenchymal (M), a mesenchymal stem–like (MSL), and a luminal androgen receptor (LAR) subtype described by Lehmann and their colleagues. These subclasses have different pattern of pathology and survival differences, and different responses to systemic treatment. More differentiated ones are expected to secrete more CA 15-3 and CEA and and give less response to systemic chemotherapy

No competing interests declared.

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Nomograms for Predicting the Prognostic Value of Pre-Therapeutic CA15-3 and CEA Serum Levels in TNBC Patients

Nomograms for Predicting the Prognostic Value of Pre-Therapeutic CA15-3 and CEA Serum Levels in TNBC Patients

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Subclasses of TNBC and serum CA 15-3 and CEA levels

Posted by kaltundag on 01 Sep 2016 at 20:22 GMT