Influence of pre-pregnancy body mass index (p-BMI) and gestational weight gain (GWG) on DNA methylation and protein expression of obesogenic genes in umbilical vein

Erika Chavira-Suárez; Angélica Jazmín Ramírez-Mendieta; Sofía Martínez-Gutiérrez; Paola Zárate-Segura; Jorge Beltrán-Montoya; Nidia Carolina Espinosa-Maldonado; Juan Carlos de la Cerda-Ángeles; Felipe Vadillo-Ortega

doi:10.1371/journal.pone.0226010

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Open Access

Peer-reviewed

Research Article

Influence of pre-pregnancy body mass index (p-BMI) and gestational weight gain (GWG) on DNA methylation and protein expression of obesogenic genes in umbilical vein

Erika Chavira-Suárez ,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Writing – original draft

* E-mail: erika@bq.unam.mx

Affiliations Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico, Unidad de Vinculación Científica de la Facultad de Medicina, Universidad Nacional Autónoma de México en el Instituto Nacional de Medicina Genómica, Mexico City, Mexico

http://orcid.org/0000-0002-1012-2760

⨯
Angélica Jazmín Ramírez-Mendieta ,

Contributed equally to this work with: Angélica Jazmín Ramírez-Mendieta, Sofía Martínez-Gutiérrez

Roles Data curation, Methodology, Writing – review & editing

Affiliation Unidad de Vinculación Científica de la Facultad de Medicina, Universidad Nacional Autónoma de México en el Instituto Nacional de Medicina Genómica, Mexico City, Mexico
⨯
Sofía Martínez-Gutiérrez ,

Contributed equally to this work with: Angélica Jazmín Ramírez-Mendieta, Sofía Martínez-Gutiérrez

Roles Data curation, Methodology, Writing – review & editing

Affiliation Unidad de Vinculación Científica de la Facultad de Medicina, Universidad Nacional Autónoma de México en el Instituto Nacional de Medicina Genómica, Mexico City, Mexico
⨯
Paola Zárate-Segura,

Roles Methodology, Resources, Writing – review & editing

Affiliation Laboratorio de Medicina Traslacional, Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City, Mexico

http://orcid.org/0000-0002-5639-9503

⨯
Jorge Beltrán-Montoya,

Roles Resources, Writing – review & editing

Affiliation Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Mexico City, Mexico
⨯
Nidia Carolina Espinosa-Maldonado,

Roles Resources, Writing – review & editing

Affiliation Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico
⨯
Juan Carlos de la Cerda-Ángeles,

Roles Resources, Writing – review & editing

Affiliation Hospital General Dr. Enrique Cabrera, Secretaría de Salud CDMX, Mexico City, Mexico
⨯
Felipe Vadillo-Ortega

Roles Supervision, Validation, Visualization, Writing – review & editing

Affiliation Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico
⨯

Influence of pre-pregnancy body mass index (p-BMI) and gestational weight gain (GWG) on DNA methylation and protein expression of obesogenic genes in umbilical vein

Erika Chavira-Suárez,
Angélica Jazmín Ramírez-Mendieta,
Sofía Martínez-Gutiérrez,
Paola Zárate-Segura,
Jorge Beltrán-Montoya,
Nidia Carolina Espinosa-Maldonado,
Juan Carlos de la Cerda-Ángeles,
Felipe Vadillo-Ortega

Published: December 3, 2019
https://doi.org/10.1371/journal.pone.0226010

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PLOS One Editors’ Note

Posted by PLOS_ONE_Group on 08 Dec 2025 at 11:00 GMT

Concerns were raised regarding the peer review process for this article. The Editors investigated and concluded that the article’s publication is supported based on expert input that was not affected by the concerns.

No competing interests declared.

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DNA methylation
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Obesity
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Pregnancy
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Umbilical veins
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Leptin
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Nutrition
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Habits
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Weight gain
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Influence of pre-pregnancy body mass index (p-BMI) and gestational weight gain (GWG) on DNA methylation and protein expression of obesogenic genes in umbilical vein

Influence of pre-pregnancy body mass index (p-BMI) and gestational weight gain (GWG) on DNA methylation and protein expression of obesogenic genes in umbilical vein

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PLOS One Editors’ Note

Posted by PLOS_ONE_Group on 08 Dec 2025 at 11:00 GMT