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Hardly a novel observation.

Posted by IrvingKushner on 06 Mar 2015 at 17:01 GMT

From Kushner I, Rzewnicki D, Samols D. What does minor elevation of C-reactive protein signify? Am J Med 119, 166.e17-166.e28, 2006.
“Strikingly, minor elevation of CRP predicts a greater likelihood of dying in individuals with different diseases (Table 10). People with worse disease (attested by higher CRP levels) can be expected to have a poorer prognosis, of course. More striking, however, are the observations that all-cause, as well as cardiovascular, mortality in apparently healthy elderly or middle-aged people is predicted by minor CRP elevation (Table 10).”

Table 10 Association of CRP with likelihood of dying

In patients admitted to ICU 240
Following stroke 249
Following acute myocardial infarction 229, 230
In patients with coronary disease or undergoing coronary angioplasty or bypass grafts 227, 234, 250,251
In patients with malignant lymphoma 252
In patients with multiple myeloma 253, 254
In patients with non-ST elevation acute coronary syndrome. 255
In women with HIV infection 256
In patients with esophageal carcinoma 257, 258
In patients undergoing renal transplant 259
In Japanese with type 2 diabetes mellitus 260
In patients with end stage renal disease on dialysis 261-265
Following surgery for colorectal cancer 266
In elderly or middle aged people 267-269

267. Harris TB, Ferrucci L, Tracy RP, et al. Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly. Am J Med. 1999;106:506-512.
268. Jager A, van Hinsbergh VW, Kostense PJ, et al. von Willebrand factor, C-reactive protein, and 5-year mortality in diabetic and nondiabetic Subjects: the Hoorn study. Arterioscler Thromb Vasc Biol. 1999;19:3071-3078.
269. Mendall MA, Strachan DP, Butland BK, et al. C-reactive protein: relation to total mortality, cardiovascular mortality and cardiovascular risk factors in men. Eur Heart J. 2000;21:1584-1590.

No competing interests declared.