Alkalinity of Neutrophil Phagocytic Vacuoles Is Modulated by HVCN1 and Has Consequences for Myeloperoxidase Activity

Adam P. Levine; Michael R. Duchen; Simon de Villiers; Peter R. Rich; Anthony W. Segal

doi:10.1371/journal.pone.0125906

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Peer-reviewed

Research Article

Alkalinity of Neutrophil Phagocytic Vacuoles Is Modulated by HVCN1 and Has Consequences for Myeloperoxidase Activity

Adam P. Levine,

Affiliation Division of Medicine, University College London, London, United Kingdom
⨯
Michael R. Duchen,

Affiliation Department of Cell and Developmental Biology, University College London, London, United Kingdom
⨯
Simon de Villiers,

Affiliation Glynn Laboratory of Bioenergetics, Department of Biology, University College London, London, United Kingdom
⨯
Peter R. Rich,

Affiliation Glynn Laboratory of Bioenergetics, Department of Biology, University College London, London, United Kingdom
⨯
Anthony W. Segal

* E-mail: t.segal@ucl.ac.uk

Affiliation Division of Medicine, University College London, London, United Kingdom
⨯

Alkalinity of Neutrophil Phagocytic Vacuoles Is Modulated by HVCN1 and Has Consequences for Myeloperoxidase Activity

Adam P. Levine,
Michael R. Duchen,
Simon de Villiers,
Peter R. Rich,
Anthony W. Segal

Published: April 17, 2015
https://doi.org/10.1371/journal.pone.0125906
See the preprint

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Stoichiometry of NADPH, electrons and protons

Posted by asegal on 10 May 2015 at 09:44 GMT

The oxidation of NADPH generates two electrons, not one as shown in Figure 1. The stoichiometry of electrons to protons is 1:1.

Cross AR, Segal AW. The NADPH oxidase of professional phagocytes - prototype of the NOX electron transport chain systems. Biochim Biophys Acta. 2004; 1657(1):1-22.

No competing interests declared.

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Alkalinity of Neutrophil Phagocytic Vacuoles Is Modulated by HVCN1 and Has Consequences for Myeloperoxidase Activity

Alkalinity of Neutrophil Phagocytic Vacuoles Is Modulated by HVCN1 and Has Consequences for Myeloperoxidase Activity

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Stoichiometry of NADPH, electrons and protons

Posted by asegal on 10 May 2015 at 09:44 GMT