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Affinity Improvement of a Therapeutic Antibody by Structure-Based Computational Design: Generation of Electrostatic Interactions in the Transition State Stabilizes the Antibody-Antigen Complex
Kiyoshi M,
Caaveiro JMM,
Miura E,
Nagatoishi S,
Nakakido M,
et al.
(2014)
Affinity Improvement of a Therapeutic Antibody by Structure-Based Computational Design: Generation of Electrostatic Interactions in the Transition State Stabilizes the Antibody-Antigen Complex.
PLOS ONE 9(1): e87099.
https://doi.org/10.1371/journal.pone.0087099