Computational investigation of African natural products as Helicobacter pylori shikimate kinase inhibitors

Hari Ram Sharma Paudel

doi:10.1371/journal.pone.0346899

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Open Access

Peer-reviewed

Research Article

Computational investigation of African natural products as Helicobacter pylori shikimate kinase inhibitors

Hari Ram Sharma Paudel

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: hareram.poudel@trc.tu.edu.np

Affiliation Department of Chemistry, Tri-Chandra Campus, Tribhuvan University, Kathmandu, Nepal

https://orcid.org/0000-0003-0815-7240

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Computational investigation of African natural products as Helicobacter pylori shikimate kinase inhibitors

Hari Ram Sharma Paudel

Published: April 20, 2026
https://doi.org/10.1371/journal.pone.0346899

About the Authors

Hari Ram Sharma Paudel

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: hareram.poudel@trc.tu.edu.np

Affiliation Department of Chemistry, Tri-Chandra Campus, Tribhuvan University, Kathmandu, Nepal

https://orcid.org/0000-0003-0815-7240

Competing Interests

The authors have declared that no competing interests exist.

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Hydrogen bonding
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Biochemical simulations
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Molecular dynamics
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Molecular docking
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Antibiotics
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Enzyme inhibitors
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Protein interactions
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Protein structure databases
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