About the Authors

Melissa M. Heintz

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

mheintz@toxstrategies.com

Affiliation ToxStrategies LLC, Asheville, North Carolina, United States of America

Chad M. Thompson

Roles Conceptualization, Formal analysis, Visualization, Writing – original draft, Writing – review & editing

Affiliation ToxStrategies LLC, Katy, Texas, United States of America

Jeffrey C. Wolf

Roles Formal analysis, Writing – review & editing

Affiliation Experimental Pathology Laboratories, Inc., Sterling, Virginia, United States of America

John M. Rogers

Roles Conceptualization, Methodology, Writing – review & editing

Affiliation ToxStrategies LLC, Raleigh, North Carolina, United States of America

Laurie C. Haws

Roles Funding acquisition, Resources, Writing – review & editing

Affiliation ToxStrategies LLC, Austin, Texas, United States of America

Competing Interests

The authors declared the following potential perceived conflicts of interest with respect to the research, authorship, and/or publication of this article: This work was funded by The Chemours Company FC, LLC. The funder had no role in study design, data collection and analysis, or preparation of the original manuscript draft. However, the funder was given the opportunity to review the draft manuscript. The purpose of this review by the funder was for the authors to receive input on the clarity of the science presented but not on the interpretation of research results. The authors’ scientific conclusions and professional judgments were not subject to the funder’s control; the contents of this manuscript solely reflect the view of the authors. M.M. Heintz, C.M. Thompson, J.M. Rogers, and L.C. Haws are employees of ToxStrategies LLC, a private consulting firm that provides services to private and public organizations for toxicology, epidemiology, and risk assessment issues. Their contributions to the research reported in this article were conducted during the normal course of employment at ToxStrategies. This does not alter our adherence to PLOS ONE policies on sharing data and materials. There are no patents, products in development or marketed products associated with this research to declare.