About the Authors

Moritz Saxenhofer

Roles Conceptualization, Formal analysis, Visualization, Writing – original draft

moritz.saxenhofer@cslbehring.com

Affiliations CSL Behring, CSL Biologics Research Centre, Bern, Switzerland,, Swiss Institute for Translational and Entrepreneurial Medicine, sitem-insel, Bern, Switzerland

Daniel Couto

Roles Methodology, Writing – review & editing

Affiliations CSL Behring, CSL Biologics Research Centre, Bern, Switzerland,, Swiss Institute for Translational and Entrepreneurial Medicine, sitem-insel, Bern, Switzerland

Sandra Mena Perez

Roles Investigation, Writing – review & editing

Affiliations CSL Behring, CSL Biologics Research Centre, Bern, Switzerland,, Swiss Institute for Translational and Entrepreneurial Medicine, sitem-insel, Bern, Switzerland

Marlies Illi

Roles Investigation, Writing – review & editing

Affiliations CSL Behring, CSL Biologics Research Centre, Bern, Switzerland,, Swiss Institute for Translational and Entrepreneurial Medicine, sitem-insel, Bern, Switzerland

Justine Brodard

Roles Investigation, Writing – review & editing

Affiliation Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, Bern, Switzerland

Linet Njue

Roles Investigation, Writing – review & editing

Affiliation Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, Bern, Switzerland

Ioannis Chanias

Roles Investigation, Writing – review & editing

Affiliation Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, Bern, Switzerland

Cesare Medri

Roles Investigation, Writing – review & editing

Current address: Department of Hematology, USB, Basel University Hospital, Switzerland

Affiliation Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, Bern, Switzerland

Gerasimos Tsilimidos

Roles Investigation, Writing – review & editing

Affiliation Service and Central Laboratory of Haematology, Department of Oncology and Department of Laboratory Medicines and Pathology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland

Nicole Hadorn

Roles Investigation, Writing – review & editing

Affiliation Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, Bern, Switzerland

Christelle Chirlias

Roles Investigation, Writing – review & editing

Affiliation Service and Central Laboratory of Haematology, Department of Oncology and Department of Laboratory Medicines and Pathology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland

Ana-Patricia Batista Mesquita

Roles Investigation, Writing – review & editing

Affiliation Service and Central Laboratory of Haematology, Department of Oncology and Department of Laboratory Medicines and Pathology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland

Lucas Veuthey

Roles Investigation, Writing – review & editing

Affiliation Service and Central Laboratory of Haematology, Department of Oncology and Department of Laboratory Medicines and Pathology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland

Anna Schnell

Roles Investigation, Writing – review & editing

Affiliations CSL Behring, CSL Biologics Research Centre, Bern, Switzerland,, Swiss Institute for Translational and Entrepreneurial Medicine, sitem-insel, Bern, Switzerland

Stefanie Graeter

Roles Methodology, Writing – review & editing

Affiliations CSL Behring, CSL Biologics Research Centre, Bern, Switzerland,, Swiss Institute for Translational and Entrepreneurial Medicine, sitem-insel, Bern, Switzerland

Gregory J. Kato

Roles Investigation, Writing – review & editing

Affiliation CSL Behring, Clinical Research & Development, King of Prussia, Pennsylvania, United States of America

Jacqueline Adam

Roles Investigation, Writing – review & editing

Affiliations CSL Behring, CSL Biologics Research Centre, Bern, Switzerland,, Swiss Institute for Translational and Entrepreneurial Medicine, sitem-insel, Bern, Switzerland

Ramona Merki

Roles Investigation, Writing – review & editing

Affiliation Oncology and Hematology Department, Aarau Cantonal Hospital, Aarau, Switzerland

Emmanuel Levrat

Roles Investigation, Writing – review & editing

Affiliation Department of Hemato-Oncology, Hôpital Cantonal Fribourg, Fribourg, Switzerland

Kaveh Samii

Roles Investigation, Writing – review & editing

Affiliation Clinical Hematology Unit, Geneva University Hospitals (HUG), Geneva, Switzerland

Mila Keiser

Roles Investigation, Writing – review & editing

Affiliation Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, Bern, Switzerland

Kathrin Susann Bieri

Roles Project administration, Writing – review & editing

Affiliation University of Bern, Department of Clinical Research, Bern, Switzerland

Alan G. Haynes

Roles Formal analysis, Writing – review & editing

Affiliation University of Bern, Department of Clinical Research, Bern, Switzerland

Anne Angelillo-Scherrer

Roles Supervision, Writing – review & editing

Affiliation Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, Bern, Switzerland

Lorenzo Alberio

Roles Supervision, Writing – review & editing

Affiliation Service and Central Laboratory of Haematology, Department of Oncology and Department of Laboratory Medicines and Pathology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland

Francesco Grandoni

Roles Supervision, Writing – review & editing

Affiliation Service and Central Laboratory of Haematology, Department of Oncology and Department of Laboratory Medicines and Pathology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland

Mathilde Gavillet

Contributed equally to this work with: Mathilde Gavillet, Thomas Gentinetta, Alicia Rovó, Alexander Schaub

Roles Conceptualization, Investigation, Writing – review & editing

Affiliation Service and Central Laboratory of Haematology, Department of Oncology and Department of Laboratory Medicines and Pathology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland

Thomas Gentinetta

Contributed equally to this work with: Mathilde Gavillet, Thomas Gentinetta, Alicia Rovó, Alexander Schaub

Roles Conceptualization, Methodology, Writing – review & editing

Affiliations CSL Behring, CSL Biologics Research Centre, Bern, Switzerland,, Swiss Institute for Translational and Entrepreneurial Medicine, sitem-insel, Bern, Switzerland

Alicia Rovó

Contributed equally to this work with: Mathilde Gavillet, Thomas Gentinetta, Alicia Rovó, Alexander Schaub

Roles Conceptualization, Investigation, Supervision, Writing – review & editing

Affiliation Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, Bern, Switzerland

Alexander Schaub

Contributed equally to this work with: Mathilde Gavillet, Thomas Gentinetta, Alicia Rovó, Alexander Schaub

Roles Conceptualization, Supervision, Writing – review & editing

Affiliations CSL Behring, CSL Biologics Research Centre, Bern, Switzerland,, Swiss Institute for Translational and Entrepreneurial Medicine, sitem-insel, Bern, Switzerland

Competing Interests

I have read the journal’s policy, and the authors of this manuscript have the following competing interests: MS, DC, SMP, MI, AS, SG, GJK, JA, TG, and AS are employees of CSL Behring. GJK is named on the patent WO2016077386A1 held by the US DHHS for the formulation of topical sodium nitrite, granted April 30, 2019. AR received research funding from CSL Behring for the conduct of this study. Outside of the submitted work, AR acknowledges research funding or honoraria from Novartis, Alexion, OrPha Swiss, and Sobi, and reports consultancy to BMS, Blueprint, GSK, and Pfizer. These commercial affiliations do not alter our adherence to PLOS ONE policies on sharing data and materials.