Evaluation of the mechanism underlying melatonin action in cholestatic liver disease treatment via network pharmacology, molecular docking, and in vivo experiments

Tao Li; Jiang ZhenYu; Wang Jing

doi:10.1371/journal.pone.0342978

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Open Access

Peer-reviewed

Research Article

Evaluation of the mechanism underlying melatonin action in cholestatic liver disease treatment via network pharmacology, molecular docking, and in vivo experiments

Tao Li,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Validation, Visualization, Writing – original draft

Affiliation Graduate School of Baotou Medical College, Baotou, China
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Jiang ZhenYu ,

Roles Resources, Writing – review & editing

* E-mail: Jzhy1981@foxmail.com (JZ); wangjinghappy2004@126.com (WJ)

Affiliation The Second Affiliated Hospital of Baotou Medical College, Baotou, China
⨯
Wang Jing

Roles Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

* E-mail: Jzhy1981@foxmail.com (JZ); wangjinghappy2004@126.com (WJ)

Affiliation The Second Affiliated Hospital of Baotou Medical College, Baotou, China

https://orcid.org/0000-0002-9332-5706

⨯

Evaluation of the mechanism underlying melatonin action in cholestatic liver disease treatment via network pharmacology, molecular docking, and in vivo experiments

Tao Li,
Jiang ZhenYu,
Wang Jing

Published: February 27, 2026
https://doi.org/10.1371/journal.pone.0342978

About the Authors

Tao Li

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Validation, Visualization, Writing – original draft

Affiliation Graduate School of Baotou Medical College, Baotou, China

Jiang ZhenYu

Roles Resources, Writing – review & editing

* E-mail: Jzhy1981@foxmail.com (JZ); wangjinghappy2004@126.com (WJ)

Affiliation The Second Affiliated Hospital of Baotou Medical College, Baotou, China

Wang Jing

Roles Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

* E-mail: Jzhy1981@foxmail.com (JZ); wangjinghappy2004@126.com (WJ)

Affiliation The Second Affiliated Hospital of Baotou Medical College, Baotou, China

https://orcid.org/0000-0002-9332-5706

Competing Interests

The authors have declared that no competing interests exist.

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Liver diseases
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Melatonin
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Liver fibrosis
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Protein interaction networks
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Estrogens
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Inflammatory diseases
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Fibrosis
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Molecular docking
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