Development of niosomal nanoparticles loaded with cisplatin and vorinostat combination for cancer therapy

Hazar Ali; Zainab Lafi; Naeem Shalan

doi:10.1371/journal.pone.0342344

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Open Access

Peer-reviewed

Research Article

Development of niosomal nanoparticles loaded with cisplatin and vorinostat combination for cancer therapy

Hazar Ali,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

Affiliations Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman, Jordan, Pharmacological and Diagnostic Research Center, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman, Jordan
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Zainab Lafi ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Supervision, Validation, Writing – review & editing

* E-mail: z.lafi@ammanu.edu.jo

Affiliations Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman, Jordan, Pharmacological and Diagnostic Research Center, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman, Jordan

https://orcid.org/0000-0003-2847-2416

⨯
Naeem Shalan

Roles Supervision, Writing – review & editing

Affiliations Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman, Jordan, Pharmacological and Diagnostic Research Center, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman, Jordan
⨯

Development of niosomal nanoparticles loaded with cisplatin and vorinostat combination for cancer therapy

Hazar Ali,
Zainab Lafi,
Naeem Shalan

Published: February 6, 2026
https://doi.org/10.1371/journal.pone.0342344

About the Authors

Hazar Ali

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

Affiliations Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman, Jordan, Pharmacological and Diagnostic Research Center, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman, Jordan

Zainab Lafi

Roles Conceptualization, Data curation, Formal analysis, Investigation, Supervision, Validation, Writing – review & editing

* E-mail: z.lafi@ammanu.edu.jo

https://orcid.org/0000-0003-2847-2416

Naeem Shalan

Roles Supervision, Writing – review & editing

Competing Interests

Authors declared no conflict of interest in this study.

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Apoptosis
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Cancer treatment
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Vesicles
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Lung and intrathoracic tumors
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Nanoparticles
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Drug therapy
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Drug interactions
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Transmission electron microscopy
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