About the Authors

Sarah F. McGough

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

mcgough.sarah@gene.com (SFM); tibs@stanford.edu (RT)

Affiliation Computational Sciences, Genentech Research and Early Development, Genentech, Inc., South San Francisco, California, United States of America

Svetlana Lyalina

Roles Data curation, Formal analysis, Methodology, Visualization, Writing – original draft, Writing – review & editing

Affiliation Safety Science, Product Development, Genentech, Inc., South San Francisco, California, United States of America

Devin Incerti

Roles Formal analysis, Methodology, Writing – review & editing

Affiliation Data Sciences, Product Development, Genentech, Inc., South San Francisco, California, United States of America

Yunru Huang

Roles Formal analysis, Methodology, Writing – review & editing

Affiliation Data Sciences, Product Development, Genentech, Inc., South San Francisco, California, United States of America

Stefka Tyanova

Roles Formal analysis, Methodology, Writing – review & editing

Affiliation Data Sciences, Product Development, Genentech, Inc., South San Francisco, California, United States of America

Kieran Mace

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Writing – review & editing

Affiliation Data Sciences, Product Development, Genentech, Inc., South San Francisco, California, United States of America

Chris Harbron

Roles Methodology, Supervision, Writing – review & editing

Affiliation Data Sciences, Product Development, F. Hoffmann-La Roche, Ltd., Welwyn Garden City, United Kingdom

Ryan Copping

Roles Conceptualization, Funding acquisition, Resources, Writing – review & editing

Affiliation Computational Sciences, Genentech Research and Early Development, Genentech, Inc., South San Francisco, California, United States of America

Balasubramanian Narasimhan

Contributed equally to this work with: Balasubramanian Narasimhan

Roles Methodology, Software, Supervision, Writing – review & editing

Affiliations Department of Statistics, Stanford University, Stanford, California, United States of America, Department of Biomedical Data Sciences, Stanford University, Stanford, California, United States of America

Robert Tibshirani

Roles Methodology, Software, Supervision, Writing – review & editing

mcgough.sarah@gene.com (SFM); tibs@stanford.edu (RT)

Affiliations Department of Statistics, Stanford University, Stanford, California, United States of America, Department of Biomedical Data Sciences, Stanford University, Stanford, California, United States of America

Competing Interests

I have read the journal’s policy and the authors of this manuscript have the following competing interests: S.F.M., S.L., D.I., Y.H., S.T., K.M., C.H., and R.C. were full-time employees of Genentech, Inc., a member of the Roche Group, at the time this work was completed. R.T. and B.N. were paid consultants for Genentech, Inc. at the time this work was completed. The affiliations with Genentech, Inc. do not alter the authors’ adherence to PLOS ONE policies on sharing data and materials.