About the Authors

Matthew J. Wolf

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Resources, Writing – review & editing

Affiliation Department of Medicine, University of Virginia, Charlottesville, Virginia, United States of America

Soumaya El Moghrabi

Roles Investigation, Methodology, Visualization, Writing – review & editing

Affiliation INSERM, UMRS 1138, Centre de Recherche des Cordeliers, Sorbonne Université, Université de Paris, Paris, France

Roberto Palacios-Ramirez

Roles Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

Current Address: Unidad de Excelencia Instituto de Biología y Genética Molecular (IBGM), Universidad de Valladolid-CSIC, Valladolid, Spain

Affiliation INSERM, UMRS 1138, Centre de Recherche des Cordeliers, Sorbonne Université, Université de Paris, Paris, France

Krister Bamberg

Roles Conceptualization, Data curation, Formal analysis, Resources, Writing – original draft, Writing – review & editing

krister.bamberg@astrazeneca.com

Affiliation Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden

Leigh A. Bradley

Roles Investigation, Writing – review & editing

Affiliation Department of Medicine, University of Virginia, Charlottesville, Virginia, United States of America

Frederick H. Epstein

Roles Conceptualization, Data curation, Formal analysis, Methodology, Visualization, Resources, Software, Writing – review & editing

Affiliation Department of Medicine, University of Virginia, Charlottesville, Virginia, United States of America

Judith Hartleib-Geschwindner

Roles Conceptualization, Writing – original draft, Writing – review & editing

Affiliation Late Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden

Frédéric Jaisser

Roles Conceptualization, Formal analysis, Methodology, Resources, Visualization, Writing – original draft, Writing – review & editing

Affiliations INSERM, UMRS 1138, Centre de Recherche des Cordeliers, Sorbonne Université, Université de Paris, Paris, France, Université de Lorraine, INSERM Centre d’Investigations Cliniques-Plurithématique 1433, UMR 1116, CHRU de Nancy, French-Clinical Research, Infrastructure Network (F-CRIN) INI-CRCT, Nancy, France

Competing Interests

I have read the journal’s policy and the authors of this manuscript have the following competing interests: KB and JH-G are employees of, and stockholders in, AstraZeneca. MJW, LAB, SEM, RP-R, FHE: Nothing to disclose. FJ: Received grants from AstraZeneca and Bayer, and honoraria from AstraZeneca, Bayer, and Boehringer. This does not alter our adherence to PLOS ONE policies on sharing data and materials.