https://orcid.org/0000-0002-4787-742X
About the Authors
- Richard B. Warren
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Roles Conceptualization, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing
¶‡ First author.
Affiliations Dermatology Centre, Northern Care Alliance NHS Foundation Trust, Manchester, United Kingdom, NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom
- Hamish J. A. Hunter
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Roles Conceptualization, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing
Affiliations Dermatology Centre, Northern Care Alliance NHS Foundation Trust, Manchester, United Kingdom, NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom, Medicines Evaluation Unit, Manchester, United Kingdom
- Kim A. Papp
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Roles Conceptualization, Methodology, Visualization, Writing – original draft, Writing – review & editing
Affiliations Alliance Clinical Research and Probity Medical Research, Waterloo, Ontario, Canada, Division of Dermatology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
- Kenneth B. Gordon
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Roles Conceptualization, Methodology, Visualization, Writing – original draft, Writing – review & editing
Affiliation Dermatology, Medical College of Wisconsin, Wauwatosa, Wisconsin, United States of America
- Meina T. Tang
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Roles Conceptualization, Data curation, Formal analysis, Methodology, Supervision, Visualization, Writing – original draft, Writing – review & editing
Affiliation DICE Therapeutics, a wholly owned subsidiary of Eli Lilly and Company, South San Francisco, California, United States of America
- Jeffrey V. Enejosa
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Roles Conceptualization, Formal analysis, Methodology, Visualization, Writing – original draft, Writing – review & editing
Affiliation DICE Therapeutics, a wholly owned subsidiary of Eli Lilly and Company, South San Francisco, California, United States of America
- Kuan-Chieh Huang
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Roles Data curation, Formal analysis, Methodology, Visualization, Writing – original draft, Writing – review & editing
Affiliation DICE Therapeutics, a wholly owned subsidiary of Eli Lilly and Company, South San Francisco, California, United States of America
- Debasish Raha
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Roles Data curation, Methodology, Visualization, Writing – original draft, Writing – review & editing
Affiliation DICE Therapeutics, a wholly owned subsidiary of Eli Lilly and Company, South San Francisco, California, United States of America
- Hashini M. Batugedara
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Roles Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing
Affiliation DICE Therapeutics, a wholly owned subsidiary of Eli Lilly and Company, South San Francisco, California, United States of America
- Craig Skinner
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Roles Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing
Affiliation DICE Therapeutics, a wholly owned subsidiary of Eli Lilly and Company, South San Francisco, California, United States of America
- Philip A. Kobel
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Roles Investigation, Visualization, Writing – original draft, Writing – review & editing
Affiliation DICE Therapeutics, a wholly owned subsidiary of Eli Lilly and Company, South San Francisco, California, United States of America
- Peter M. Rademacher
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Roles Investigation, Visualization, Writing – original draft, Writing – review & editing
Affiliation DICE Therapeutics, a wholly owned subsidiary of Eli Lilly and Company, South San Francisco, California, United States of America
- Nico Ghilardi
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Roles Conceptualization, Data curation, Formal analysis, Methodology, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing
* E-mail: nico.ghilardi@lilly.com
Affiliation DICE Therapeutics, a wholly owned subsidiary of Eli Lilly and Company, South San Francisco, California, United States of America
- Paul Fatheree
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Roles Project administration, Visualization, Writing – original draft, Writing – review & editing
Affiliation DICE Therapeutics, a wholly owned subsidiary of Eli Lilly and Company, South San Francisco, California, United States of America
- John R. Jacobsen
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Roles Data curation, Formal analysis, Funding acquisition, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing
Affiliation DICE Therapeutics, a wholly owned subsidiary of Eli Lilly and Company, South San Francisco, California, United States of America
- Timothy T. Lu
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Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing
Affiliation DICE Therapeutics, a wholly owned subsidiary of Eli Lilly and Company, South San Francisco, California, United States of America
Competing Interests
I have read the journal’s policy and the authors of this manuscript have the following competing interests: RBW received research grants from AbbVie, Almirall, Eli Lilly and Company, Janssen, Leo Pharma, Novartis, Pfizer, and UCB; received consulting fees from AbbVie, Almirall, Amgen, Arena, Astellas, Avillion, Biogen, Boehringer Ingelheim, Bristol-Myers Squibb, Celgene, Eli Lilly and Company, DICE Therapeutics, GSK, Janssen, Leo Pharma, Novartis, Pfizer, Sanofi, Sun Pharma, UBC, and UNION Therapeutics; received payment or honoraria from AbbVie, Almirall, Boehringer Ingelheim, Bristol-Myers Squibb, Celgene, Eli Lilly and Company, Janssen, Leo Pharma, Novartis, Pfizer, Sanofi, Sun Pharma, and UCB; and has participated in meetings or advisory boards for AbbVie, Almirall, DICE Therapeutics, Eli Lilly and Company, Leo Pharma, Novartis, Regeneron, Sanofi, UCB, and UNION Therapeutics. HJAH received research grants from Janssen, Merck Serono, and Pfizer; acted as an investigator for AbbVie, Almirall, Bayer Pharmaceuticals, DICE Therapeutics, Eli Lilly and Company, Evelo Biosciences, Janssen, Leo Pharma, Novartis, ONO Pharmaceutical Co. Ltd., Sanofi, UCB, and UNION Therapeutics; received consulting fees and honoraria from AbbVie, Almirall, DICE Therapeutics, Eli Lilly and Company, Janssen, La Roche-Posay, Leo Pharma, Novartis, Regeneron, Sanofi, UCB, and UNION Therapeutics; and participated in advisory boards for AbbVie, Almirall, DICE Therapeutics, Eli Lilly and Company, Leo Pharma, Novartis, Regeneron, Sanofi, UCB, and UNION Therapeutics. KAP received honoraria and/or grants from AbbVie, Acelyrin, Akros, Alumis, Amgen, Arcutis, Bausch Health/Valeant, Boehringer Ingelheim, Bristol-Myers Squibb, Can-Fite Biopharma, Celltrion, Concert Pharmaceuticals, Dermavant, Dermira, DICE Therapeutics, Eli Lilly and Company, Evelo Biosciences, Forbion, Galderma, Horizon Therapeutics, Incyte, Janssen, Kymab, Kyowa Hakko Kirin, Leo Pharma, Meiji Seika Pharma, Mitsubishi Pharma, Nimbus Therapeutics, Novartis, Pfizer, Reistone, Sanofi, Sandoz, Sun Pharma, Takeda, Tarsus Pharmaceuticals, UCB, and Zai Lab. KBG has received consulting fees from AbbVie, Almirall, Amgen, Boehringer Ingelheim, Bristol-Myers Squibb, Celgene, Dermira, Eli Lilly and Company, Janssen, Novartis, Pfizer, Sun Pharma, and UCB; and has received research support from AbbVie, Bristol-Myers Squibb, Celgene, Eli Lilly and Company, Janssen, Novartis, and UCB. MTT, DR, HMB, CS, PAK, NG, and PF are employees of DICE Therapeutics, a wholly owned subsidiary of Eli Lilly and Company. PF and JRJ appear on the patent for DC-806. JVE, KCH, PMR, JRJ, and TTL were former employees of DICE Therapeutics, a wholly owned subsidiary of Eli Lilly and Company, at the time of the study. The authors have no additional financial interests. This commercial affiliation does not alter our adherence to PLOS ONE policies on sharing data and materials.