Mechanistic study of plastic monomers in gestational diabetes mellitus: A network toxicology and molecular docking approach

Yingying Feng; Tingting Huang

doi:10.1371/journal.pone.0339863

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Open Access

Peer-reviewed

Research Article

Mechanistic study of plastic monomers in gestational diabetes mellitus: A network toxicology and molecular docking approach

Yingying Feng,

Roles Data curation, Project administration, Visualization, Writing – original draft

Affiliation Department of Obstetrics, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Hongshan District, Wuhan, China
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Tingting Huang

Roles Conceptualization, Methodology, Supervision, Validation, Writing – review & editing

* E-mail: tingtinghuang312@163.com

Affiliation Department of Obstetrics, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Hongshan District, Wuhan, China

https://orcid.org/0009-0003-8383-1204

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Mechanistic study of plastic monomers in gestational diabetes mellitus: A network toxicology and molecular docking approach

Yingying Feng,
Tingting Huang

Published: December 29, 2025
https://doi.org/10.1371/journal.pone.0339863

About the Authors

Yingying Feng

Roles Data curation, Project administration, Visualization, Writing – original draft

Affiliation Department of Obstetrics, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Hongshan District, Wuhan, China

Tingting Huang

Roles Conceptualization, Methodology, Supervision, Validation, Writing – review & editing

* E-mail: tingtinghuang312@163.com

Affiliation Department of Obstetrics, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Hongshan District, Wuhan, China

https://orcid.org/0009-0003-8383-1204

Competing Interests

The authors have declared that no competing interests exist.

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Monomers
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Glucose metabolism
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Insulin resistance
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Molecular docking
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Pathogenesis
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Stress signaling cascade
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Insulin signaling
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Thyroid hormones
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