About the Authors

Keiji Konishi

Roles Investigation, Project administration, Writing – original draft, Writing – review & editing

konishi@hp-infect.med.osaka-u.ac.jp

Affiliations Department of Post-infectious disease Therapeutics, Graduate School of Medicine, The University of Osaka, Osaka, Japan, Department of Infection Control and Prevention, Graduate School of Medicine, The University of Osaka, Osaka, Japan, AIDS Medical Center, NHO Osaka National Hospital, Osaka, Japan

Shungo Yamamoto

Roles Conceptualization, Methodology, Writing – review & editing

Affiliations Department of Infection Control and Prevention, Graduate School of Medicine, The University of Osaka, Osaka, Japan, Division of Fostering Required Medical Human Resources, Center for Infectious Disease Education and Research (CiDER), The University of Osaka, Osaka, Japan, Department of Transformative Protection to Infectious Disease, Graduate School of Medicine, The University of Osaka, Osaka, Japan

Ryuichi Minoda Sada

Roles Conceptualization, Methodology, Writing – review & editing

Affiliations Department of Infection Control and Prevention, Graduate School of Medicine, The University of Osaka, Osaka, Japan, Division of Fostering Required Medical Human Resources, Center for Infectious Disease Education and Research (CiDER), The University of Osaka, Osaka, Japan, Department of Transformative Protection to Infectious Disease, Graduate School of Medicine, The University of Osaka, Osaka, Japan

Kento Asano

Roles Conceptualization, Methodology, Writing – review & editing

Affiliation Academic Clinical Research Center, Department of Medical Innovation, The University of Osaka Hospital, Osaka, Japan

Daisuke Onozuka

Roles Conceptualization, Data curation, Formal analysis, Methodology, Writing – review & editing

Affiliations Department of Post-infectious disease Therapeutics, Graduate School of Medicine, The University of Osaka, Osaka, Japan, Department of Infection Control and Prevention, Graduate School of Medicine, The University of Osaka, Osaka, Japan

Shintaro Tanaka

Roles Conceptualization, Writing – review & editing

Affiliation Medical Affairs Department, Shionogi and Co., Ltd., Tokyo, Japan

Shogo Miyazawa

Roles Conceptualization, Writing – review & editing

Affiliation Data Science Department, Shionogi and Co., Ltd., Osaka, Japan

Masahiro Kinoshita

Roles Conceptualization, Writing – review & editing

Affiliation Medical Affairs Department, Shionogi and Co., Ltd., Osaka, Japan

Satoshi Kutsuna

Roles Conceptualization, Methodology, Writing – review & editing

Affiliations Department of Post-infectious disease Therapeutics, Graduate School of Medicine, The University of Osaka, Osaka, Japan, Department of Infection Control and Prevention, Graduate School of Medicine, The University of Osaka, Osaka, Japan, Division of Fostering Required Medical Human Resources, Center for Infectious Disease Education and Research (CiDER), The University of Osaka, Osaka, Japan, Department of Transformative Protection to Infectious Disease, Graduate School of Medicine, The University of Osaka, Osaka, Japan

Competing Interests

Keiji Konishi, Daisuke Onozuka, and Satoshi Kutsuna have received research support from Shionogi & Co., Ltd., Tokyo, Japan. Shungo Yamamoto, Ryuichi Minoda Sada, Kento Asano declare no competing interests. Shintaro Tanaka, Shogo Miyazawa, and Masahiro Kinoshita are full-time employees of Shionogi & Co., Ltd., and may hold stock in the company. This does not alter our adherence to PLOS ONE policies on sharing data and materials.