About the Authors

Kaja Knudsen Bergo

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

kaja.bergo@gmail.com

Affiliation Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway

Einar Sjaastad Nordén

Roles Formal analysis, Investigation, Methodology, Resources, Writing – review & editing

Affiliations Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway, Oslo New University College, Oslo, Norway

Bård Andre Bendiksen

Roles Investigation, Methodology, Resources, Writing – review & editing

Affiliations Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway, Oslo New University College, Oslo, Norway

Emil Knut Stenersen Espe

Roles Conceptualization, Investigation, Methodology, Project administration, Resources, Software, Writing – review & editing

Affiliation Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway

Gary McGinley

Roles Investigation, Resources, Writing – review & editing

Affiliation Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway

Ida Marie Hauge-Iversen

Roles Data curation, Formal analysis, Investigation, Resources, Software, Writing – review & editing

Affiliation Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway

Rizwan Iqbal Hussain

Roles Resources, Writing – review & editing

Affiliation Agiana Pharmaceuticals AS, Oslo, Norway

Sabine Leh

Roles Conceptualization, Methodology, Resources, Writing – review & editing

Affiliations Department of Clinical Medicine, University of Bergen, Bergen, Norway, Department of Pathology, Haukeland University Hospital, Bergen, Norway

Hans-Peter Marti

Roles Methodology, Resources, Writing – review & editing

Affiliations Department of Clinical Medicine, University of Bergen, Bergen, Norway, Department of Medicine, Haukeland University Hospital, Bergen, Norway

Lili Zhang

Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Writing – review & editing

Affiliation Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway

Ivar Sjaastad

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – review & editing

Affiliation Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway

Alessandro Cataliotti

Roles Conceptualization, Funding acquisition, Methodology, Resources, Supervision, Writing – review & editing

Affiliation Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway

Competing Interests

Novartis Pharmaceuticals Corporation provided the research group with Sacubitril/valsartan and valsartan used in this study free of charge. Dr. Hussain was previously employed by Novartis Pharmaceuticals Corporation at the time of study conduct, but he was no longer an employee of the company when the manuscript was draft, and it was voluntary for the study group to adjust the manuscript according to his comments. There were no restrictions or involvement from Novartis Pharmaceuticals Corporation related to the study design, data collection and analysis, decision to publish, or preparation of the manuscript. This does not alter our adherence to PLOS ONE policies on sharing data and materials.