About the Authors

Kennedy M. Peter-Marske

Roles Writing – original draft

Affiliations Merck & Co., Inc., Rahway, New Jersey, United States of America, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America,, Amgen, Thousand Oaks, California, United States of America

Xiao Zhang

Roles Conceptualization, Methodology, Project administration, Writing – review & editing

xiao.zhang6@merck.com

Affiliation Merck & Co., Inc., Rahway, New Jersey, United States of America

Tongtong Wang

Roles Formal analysis, Writing – review & editing

Affiliation Merck & Co., Inc., Rahway, New Jersey, United States of America

Xinyue Liu

Roles Conceptualization, Methodology, Writing – review & editing

Affiliation Merck & Co., Inc., Rahway, New Jersey, United States of America

Gail Fernandes

Roles Conceptualization, Methodology, Writing – review & editing

Affiliation Merck & Co., Inc., Rahway, New Jersey, United States of America

Samuel S. Engel

Roles Conceptualization, Methodology, Writing – review & editing

Affiliation Merck & Co., Inc., Rahway, New Jersey, United States of America

Ravi Shankar

Roles Conceptualization, Methodology, Writing – review & editing

Affiliation Merck & Co., Inc., Rahway, New Jersey, United States of America

Competing Interests

Xiao Zhang, Tongtong Wang, Xinyue Liu, Gail Fernandes, Samuel S Engel, and Ravi Shankar are employees of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA, and may own stock and/or hold stock options in Merck & Co., Inc., Rahway, NJ, USA. Kennedy M. Peter-Marske was supported by a Graduate Student Fellowship from Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA and by a National Institutes of Health (NIH)/National Heart, Lung, and Blood Institute National Research Service Award (T32-HL007055) during conduct of this work, and she is currently an employee of Amgen. This does not alter our adherence to PLOS ONE policies on sharing data and materials.