About the Authors

Tomoyuki Yoshida

Contributed equally to this work with: Tomoyuki Yoshida, Yoshiaki Sakamoto

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

takeyuki.kotaka@hugp.com (TK); tomoyuki.yoshida@hugp.com (TY)

Affiliation H.U. Group Research Institute G.K., Akiruno, Tokyo, Japan

Yoshiaki Sakamoto

Contributed equally to this work with: Tomoyuki Yoshida, Yoshiaki Sakamoto

Roles Data curation, Formal analysis, Methodology, Writing – review & editing

Affiliation H.U. Group Research Institute G.K., Akiruno, Tokyo, Japan

Aya Tsuruta

Roles Data curation, Software, Visualization

Affiliation H.U. Group Research Institute G.K., Akiruno, Tokyo, Japan

Risa Kimura

Roles Formal analysis, Methodology

Affiliation H.U. Group Research Institute G.K., Akiruno, Tokyo, Japan

Nozomi Shiozawa

Roles Data curation, Formal analysis, Methodology, Writing – review & editing

Affiliation H.U. Cells, Inc., Akiruno, Tokyo, Japan

Takeyuki Kotaka

Roles Conceptualization, Project administration, Supervision

takeyuki.kotaka@hugp.com (TK); tomoyuki.yoshida@hugp.com (TY)

Affiliation H.U. Group Research Institute G.K., Akiruno, Tokyo, Japan

Competing Interests

Dr. Tomoyuki Yoshida, Dr. Takeyuki Kotaka, Mr. Yoshiaki Sakamoto, Ms. Aya Tsuruta, and Ms. Risa Kimura are employees of H.U. Group Research Institute G.K.. Ms. Nozomi Shiozawa is an employee of H.U. Cells, Inc. The funder provided support in the form of salaries for authors [TY, TK, YS, AT, RK, NS], but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of these authors are articulated in the ‘Author Contributions’ section. The authors have filed a PCT (Patent Cooperation Treaty) application related to the methods and findings described in this study. The patent application number is PCT/JP2024/035622 and is currently pending. This does not alter the authors’ adherence to PLOS ONE policies on sharing data and materials, and all data necessary to replicate the findings are available as described in the manuscript.