About the Authors

Fuqiang Zhao

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Takeda Development Center America, Inc., Cambridge, Massachusetts, United States of America

Shipeng Yuan

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Takeda Development Center America, Inc., Cambridge, Massachusetts, United States of America

Charalambos Kaittanis

Roles Data curation, Formal analysis, Visualization, Writing – review & editing

Affiliation Takeda Development Center America, Inc., Cambridge, Massachusetts, United States of America

Mugdha Deshpande

Roles Resources

Affiliation Takeda Development Center America, Inc., Cambridge, Massachusetts, United States of America

Abirami Kugadas

Roles Investigation

Affiliation Takeda Development Center America, Inc., Cambridge, Massachusetts, United States of America

Katayoun Derakhchan

Roles Resources, Writing – review & editing

Affiliation Takeda Development Center America, Inc., Cambridge, Massachusetts, United States of America

Wanida Ruangsiriluk

Roles Resources

Affiliation Takeda Development Center America, Inc., Cambridge, Massachusetts, United States of America

Rizwana Islam

Roles Resources

Affiliation Takeda Development Center America, Inc., Cambridge, Massachusetts, United States of America

Natalia Boukharov

Roles Conceptualization, Data curation, Investigation, Methodology, Resources, Validation

Affiliation Takeda Development Center America, Inc., Cambridge, Massachusetts, United States of America

Paul McQuade

Roles Resources

Affiliation Takeda Development Center America, Inc., Cambridge, Massachusetts, United States of America

Johannes Tauscher

Roles Resources

Affiliation Takeda Development Center America, Inc., Cambridge, Massachusetts, United States of America

Christopher T. Winkelmann

Roles Formal analysis, Resources, Supervision, Writing – review & editing

Affiliation Takeda Development Center America, Inc., Cambridge, Massachusetts, United States of America

Talakad G. Lohith

Roles Conceptualization, Data curation, Formal analysis, Investigation, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

talakad.lohith@takeda.com

Affiliation Takeda Development Center America, Inc., Cambridge, Massachusetts, United States of America

Competing Interests

The authors have read the journal’s policy and have the following competing interests: FZ, CK, SY, MD, AK, KD, WR, RI, NB, PM, JT, CTW, TGL are employees of Takeda Pharmaceutical Company Inc. (https://www.takeda.com) and had ownership of Takeda stock during the execution of the submitted work. WR, RI and NB are current employees of Crosswalk Therapeutics (https://crosswalktherapeutics.com) and may have stock ownership outside of the submitted work. MD is a current employee of Dyno Therapeutics (https://www.dynotx.com) and may have stock ownership outside of the submitted work. AK is a current employee of WuXi AppTec (https://www.wuxiapptec.com) and may have stock ownership outside of the submitted work. KD is a current employee of Pioneering Medicines / Flagship Pioneering (https://www.flagshippioneering.com/pioneering-medicines) and may have stock ownership outside of the submitted work. There are no patents, products in development or marketed products associated with this research to declare. This does not alter our adherence to PLOS ONE policies on sharing data and materials.