About the Authors

Takenori Aoki

Contributed equally to this work with: Takenori Aoki, Sho Suzuki

Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

Affiliation Department of Cardiovascular Medicine, Shinshu University School of Medicine, Matsumoto, Japan

Sho Suzuki

Contributed equally to this work with: Takenori Aoki, Sho Suzuki

Roles Conceptualization, Data curation, Formal analysis, Methodology, Visualization, Writing – original draft, Writing – review & editing

jersey0042@gmail.com

Affiliation Department of Cardiovascular Medicine, Shinshu University School of Medicine, Matsumoto, Japan

Masatoshi Minamisawa

Roles Conceptualization, Data curation, Supervision, Writing – review & editing

Affiliation Department of Cardiovascular Medicine, Shinshu University School of Medicine, Matsumoto, Japan

Koji Yoshie

Roles Supervision, Writing – review & editing

Affiliation Department of Cardiovascular Medicine, Shinshu University School of Medicine, Matsumoto, Japan

Ken Nishikawa

Roles Supervision, Writing – review & editing

Affiliation Department of Cardiovascular Medicine, Shinshu University School of Medicine, Matsumoto, Japan

Yukari Okuma

Roles Data curation, Supervision, Writing – review & editing

Affiliation Department of Cardiovascular Medicine, Shinshu University School of Medicine, Matsumoto, Japan

Kazuhiro Kimura

Roles Data curation, Supervision, Writing – review & editing

Affiliation Department of Cardiovascular Medicine, Shinshu University School of Medicine, Matsumoto, Japan

Yasushi Ueki

Roles Data curation, Supervision, Writing – review & editing

Affiliation Department of Cardiovascular Medicine, Shinshu University School of Medicine, Matsumoto, Japan

Yasutaka Oguchi

Roles Data curation, Supervision, Writing – review & editing

Affiliation Department of Cardiovascular Medicine, Shinshu University School of Medicine, Matsumoto, Japan

Tamon Kato

Roles Data curation, Supervision, Writing – review & editing

Affiliation Department of Cardiovascular Medicine, Shinshu University School of Medicine, Matsumoto, Japan

Tatsuya Saigusa

Roles Data curation, Supervision, Writing – review & editing

Affiliation Department of Cardiovascular Medicine, Shinshu University School of Medicine, Matsumoto, Japan

Soichiro Ebisawa

Roles Data curation, Supervision, Writing – review & editing

Affiliation Department of Cardiovascular Medicine, Shinshu University School of Medicine, Matsumoto, Japan

Ayako Okada

Roles Data curation, Supervision, Writing – review & editing

Affiliation Department of Cardiovascular Medicine, Shinshu University School of Medicine, Matsumoto, Japan

Hirohiko Motoki

Roles Conceptualization, Data curation, Project administration, Resources, Supervision, Writing – review & editing

Affiliation Department of Cardiovascular Medicine, Shinshu University School of Medicine, Matsumoto, Japan

Koichiro Kuwahara

Roles Supervision, Writing – review & editing

Affiliation Department of Cardiovascular Medicine, Shinshu University School of Medicine, Matsumoto, Japan

Competing Interests

Dr. Suzuki has received lecture fees from Abbott Medical Japan LLC, Abiomed Japan K.K., Daiichi Sankyo Co., Ltd., Heart Organization Co., Ltd., NIPRO CORPORATION, and Otsuka Pharmaceutical Co., Ltd.; manuscript fees from Nankodo Co., Ltd., NIPPONRINSHOSHA Co., Ltd., and YODOSHA Co., Ltd.; research grants from AIBA WORKS Co., Ltd., Fukuda Foundation for Medical Technology, and Shinshu Public Utility Foundation for Promotion of Medical Sciences. Dr. Minamisawa has received consulting fees from Alexion Pharma GK; payment or honoraria for lectures from Pfizer Japan Inc., Nippon Boehringer Ingelheim Co. Ltd., Sanofi K.K., AstraZeneca K.K., Toa Eiyo Ltd., Bayer Yakuhin Ltd., Takeda Pharmaceutical Company Limited, Sumitomo Pharma Co. Ltd., Janssen Pharmaceutical, Otsuka Pharmaceutical, Kowa Company Limited, Novartis Pharma., Daiichi Sankyo Company Limited., Novo Nordisk Pharma Ltd., and Alnylam Japan; and is a member of the Advisory Board for Pfizer Japan Inc. and Alexion Pharma GK. Dr. Kuwahara has received lecture fees from Astellas Pharma Inc., AstraZeneca K.K., MSD K.K., Otsuka Pharmaceutical Co., Ltd., Ono Pharmaceutical Co., Ltd., Kyowa Kirin Co., Ltd., Kowa Co., Ltd., Sanofi K.K., Sumitomo Dainippon Pharma Co., Ltd. (Sumitomo Pharma Co., Ltd.), Mitsubishi Tanabe Pharma Corp., Eli Lilly Japan K.K., Nippon Boehringer Ingelheim Co., Ltd., Novartis Pharma K.K., Novo Nordisk Pharma Ltd., Bayer Yakuhin, Ltd., Pfizer Japan Inc., and Janssen Pharmaceutical K.K.; funded research or joint research expenses from Kowa Co., Ltd., AstraZeneca K.K., Daiichi Sankyo Co., Ltd., Novo Nordisk Pharma Ltd., Amgen, Janssen Pharmaceutical K.K., Parexel International Inc., and Astellas Pharma Inc. His affiliated institution (Shinshu University School of Medicine) has received grants from Otsuka Pharmaceutical Co., Ltd., Mitsubishi Tanabe Pharma Corp., Nippon Boehringer Ingelheim Co., Ltd., and Kyowa Kirin Co., Ltd., and his department has endowed chairs from Medtronic　Japan Co. Ltd., Boston Scientific Japan K.K., Abbott Japan LLC, Japan Lifeline Co.,Ltd., Biotronik Japan, Terumo Corporation, Nipro Corporation, and Cordis Japan G.K. Medtronic Japan Co. Ltd., Boston Scientific Japan K.K., Abbott Japan LLC, Japan Lifeline Co.,Ltd., Biotronik Japan, Terumo Corporation, Nipro Corporation, and Cordis Japan G.K. Other authors have reported that they have no relationships relevant to the contents of this paper to disclose.