Exploring the molecular and biological mechanisms of host response in chickens infected with highly pathogenic avian influenza virus (H5N1): An integrative transcriptomic analysis

Sare Golpasand; Shahrokh Ghovvati; Zahra Pezeshkian

doi:10.1371/journal.pone.0332689

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Open Access

Peer-reviewed

Research Article

Exploring the molecular and biological mechanisms of host response in chickens infected with highly pathogenic avian influenza virus (H5N1): An integrative transcriptomic analysis

Sare Golpasand,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

Affiliation Department of Animal Sciences, Faculty of Agriculture, University of Guilan, Rasht, Guilan, Iran

https://orcid.org/0009-0005-7883-0770

⨯
Shahrokh Ghovvati ,

Roles Conceptualization, Project administration, Supervision, Validation, Writing – review & editing

* E-mail: Ghovvati@guilan.ac.ir

Affiliation Department of Animal Sciences, Faculty of Agriculture, University of Guilan, Rasht, Guilan, Iran

https://orcid.org/0000-0002-2016-2184

⨯
Zahra Pezeshkian

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization

Affiliations Department of Animal Sciences, Faculty of Agriculture, University of Guilan, Rasht, Guilan, Iran, BioGenTAC Inc., Technology Incubator of Agricultural Biotechnology Research Institute of Iran-North Branch (ABRII), Rasht, Iran
⨯

Exploring the molecular and biological mechanisms of host response in chickens infected with highly pathogenic avian influenza virus (H5N1): An integrative transcriptomic analysis

Sare Golpasand,
Shahrokh Ghovvati,
Zahra Pezeshkian

Published: October 3, 2025
https://doi.org/10.1371/journal.pone.0332689

About the Authors

Sare Golpasand

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

Affiliation Department of Animal Sciences, Faculty of Agriculture, University of Guilan, Rasht, Guilan, Iran

https://orcid.org/0009-0005-7883-0770

Shahrokh Ghovvati

Roles Conceptualization, Project administration, Supervision, Validation, Writing – review & editing

* E-mail: Ghovvati@guilan.ac.ir

Affiliation Department of Animal Sciences, Faculty of Agriculture, University of Guilan, Rasht, Guilan, Iran

https://orcid.org/0000-0002-2016-2184

Zahra Pezeshkian

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization

Affiliations Department of Animal Sciences, Faculty of Agriculture, University of Guilan, Rasht, Guilan, Iran, BioGenTAC Inc., Technology Incubator of Agricultural Biotechnology Research Institute of Iran-North Branch (ABRII), Rasht, Iran

Competing Interests

The authors have declared that no competing interests exist.

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Immune response
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Chickens
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H5N1
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Viral gene expression
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MicroRNAs
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Gene regulation
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Genetic interference
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Virus effects on host gene expression
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