About the Authors

Francesco D’Egidio

Contributed equally to this work with: Francesco D’Egidio, Laura Brandolini

Roles Data curation, Formal analysis, Software, Writing – original draft

Affiliation Department of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, Italy

Laura Brandolini

Contributed equally to this work with: Francesco D’Egidio, Laura Brandolini

Roles Conceptualization, Methodology, Validation, Writing – original draft

Affiliation Dompé Farmaceutici Spa, L’Aquila, Italy

Vanessa Castelli

Roles Formal analysis, Investigation, Validation

Affiliation Department of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, Italy

Massimiliano Quintiliani

Roles Software

Affiliation Department of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, Italy

Andrea Aramini

Roles Data curation, Software, Visualization

Affiliation Dompé Farmaceutici Spa, L’Aquila, Italy

Annamaria Cimini

Roles Conceptualization, Project administration, Writing – review & editing

annamaria.cimini@univaq.it (AC); marcello.allegretti@dompe.com (MA)

Affiliations Department of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, Italy, Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, United States of America

Marcello Allegretti

Roles Project administration, Validation, Writing – review & editing

annamaria.cimini@univaq.it (AC); marcello.allegretti@dompe.com (MA)

Affiliation Dompé Farmaceutici Spa, L’Aquila, Italy

Michele d’Angelo

Roles Conceptualization, Project administration, Supervision

Affiliations Department of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, Italy, Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, United States of America

Competing Interests

Laura Brandolini, Andrea Aramini and Marcello Allegretti are employees of Dompe pharmaceutical Spa This does not alter our adherence to PLOS ONE policies on sharing data and materials.