About the Authors

Maria Helane Costa Gurgel Castelo

Roles Conceptualization, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Clinical Pathology Department, DASA, São Paulo, SP, Brazil

Isac de Castro

Roles Data curation, Formal analysis, Software, Writing – original draft

Affiliation Clinical Pathology Department, DASA, São Paulo, SP, Brazil

Priscila Raupp-da-Rosa

Roles Conceptualization, Methodology, Supervision, Writing – original draft, Writing – review & editing

Priscila.raupp@novartis.com

Affiliation Evidence Generation, Novartis Biociências S.A, São Paulo, SP, Brazil

Patrícia Cristina Grenzi

Roles Conceptualization

Affiliation External Scientific Engagement, Alexion Pharmaceuticals, São Paulo, SP, Brazil

Eduardo Gomes Lima

Roles Supervision, Writing – original draft, Writing – review & editing

Affiliation Clinical Research, DASA, São Paulo, SP, Brazil

Andreza Almeida Senerchia

Roles Resources, Validation, Visualization

Affiliation Clinical Research, DASA, São Paulo, SP, Brazil

Érica Ferreira

Roles Methodology, Project administration

Affiliation Study & Site Operations (SSO) Study Start-Up, Novartis Biociências S.A., São Paulo, SP, Brazil

Flavia Paiva Proença Lobo Lopes

Roles Resources, Validation, Visualization, Writing – original draft

Affiliation Research, Education and Innovation Department, DASA, São Paulo, SP, Brazil

Competing Interests

The authors have disclosed the following potential conflicts of interest: PR is an employee and stockholder of Novartis Biociências SA. PR also holds a leadership role as an Emergent Leader in the World Heart Federation. EGL reports that Novartis made payments to DASA, their current employer, in relation to this manuscript. EGL also received honoraria as a speaker for Novartis in educational events and has served on an advisory board for Bayer. FPPLL received direct payments from Bayer for attending meetings or travel. EF is a salaried employee of Novartis Biociências SA. IC received consulting fees through their institution, ConstatBio, related to DASA. PCG was a salaried employee of Novartis Biociências SA during the preparation of this manuscript. MHCGC and AAS declared no competing interests. These commercial affiliations do not alter our adherence to PLOS ONE's policies on data and material sharing.