Causal relationship between schizophrenia and five types of dementia: A bidirectional two-sample Mendelian randomization study

Feng Tao; Shizhe Deng; Bifang Zhuo; Jingyue Liu; Xuan Liang; Jiangwei Shi; Zhihong Meng

doi:10.1371/journal.pone.0322752

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Open Access

Peer-reviewed

Research Article

Causal relationship between schizophrenia and five types of dementia: A bidirectional two-sample Mendelian randomization study

Feng Tao ,

Contributed equally to this work with: Feng Tao, Shizhe Deng, Bifang Zhuo

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

Affiliations First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China
⨯
Shizhe Deng ,

Contributed equally to this work with: Feng Tao, Shizhe Deng, Bifang Zhuo

Roles Conceptualization, Data curation, Writing – original draft

Affiliations First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China
⨯
Bifang Zhuo ,

Contributed equally to this work with: Feng Tao, Shizhe Deng, Bifang Zhuo

Roles Investigation, Visualization, Writing – original draft

Affiliations First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China
⨯
Jingyue Liu,

Roles Investigation, Visualization

Affiliations First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China
⨯
Xuan Liang,

Roles Investigation, Visualization

Affiliations First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China
⨯
Jiangwei Shi ,

Roles Supervision, Writing – review & editing

* E-mail: profmengzhihong@163.com (ZM); acustone@163.com (JS)

Affiliations First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China
⨯
Zhihong Meng

Roles Supervision, Writing – review & editing

* E-mail: profmengzhihong@163.com (ZM); acustone@163.com (JS)

Affiliations First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China

https://orcid.org/0000-0003-1397-3138

⨯

Causal relationship between schizophrenia and five types of dementia: A bidirectional two-sample Mendelian randomization study

Feng Tao,
Shizhe Deng,
Bifang Zhuo,
Jingyue Liu,
Xuan Liang,
Jiangwei Shi,
Zhihong Meng

Published: May 8, 2025
https://doi.org/10.1371/journal.pone.0322752

About the Authors

Feng Tao

Contributed equally to this work with: Feng Tao, Shizhe Deng, Bifang Zhuo

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

Affiliations First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China

Shizhe Deng

Contributed equally to this work with: Feng Tao, Shizhe Deng, Bifang Zhuo

Roles Conceptualization, Data curation, Writing – original draft

Bifang Zhuo

Contributed equally to this work with: Feng Tao, Shizhe Deng, Bifang Zhuo

Roles Investigation, Visualization, Writing – original draft

Jingyue Liu

Roles Investigation, Visualization

Xuan Liang

Roles Investigation, Visualization

Jiangwei Shi

Roles Supervision, Writing – review & editing

* E-mail: profmengzhihong@163.com (ZM); acustone@163.com (JS)

Zhihong Meng

Roles Supervision, Writing – review & editing

* E-mail: profmengzhihong@163.com (ZM); acustone@163.com (JS)

https://orcid.org/0000-0003-1397-3138

Competing Interests

The authors declare no competing interests.

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Schizophrenia
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Alzheimer's disease
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Genome-wide association studies
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Dementia
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Frontotemporal dementia
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Single nucleotide polymorphisms
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Medical risk factors
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Vascular dementia
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