Safety assessment of multiple systemic administration of human mesenchymal stem cell-conditioned medium for various chronic diseases

Norihito Inami

doi:10.1371/journal.pone.0322497

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Open Access

Peer-reviewed

Research Article

Safety assessment of multiple systemic administration of human mesenchymal stem cell-conditioned medium for various chronic diseases

Norihito Inami

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: inami@shhc.jp

Affiliation Seihoku Clinic, 775 Takawa, Oshibedani, Nishi-ku, Kobe, Hyogo, Japan

https://orcid.org/0009-0001-7672-940X

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Safety assessment of multiple systemic administration of human mesenchymal stem cell-conditioned medium for various chronic diseases

Norihito Inami

Published: May 6, 2025
https://doi.org/10.1371/journal.pone.0322497

About the Authors

Norihito Inami

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: inami@shhc.jp

Affiliation Seihoku Clinic, 775 Takawa, Oshibedani, Nishi-ku, Kobe, Hyogo, Japan

https://orcid.org/0009-0001-7672-940X

Competing Interests

The author has declared that no competing interests exist.

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Mesenchymal stem cells
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Adverse events
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Stem cell therapy
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Routes of administration
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C-reactive proteins
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Inflammation
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Physicians
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Inflammatory diseases
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