About the Authors

Wencheng Jin

Contributed equally to this work with: Wencheng Jin, Ara Cho

Roles Conceptualization, Formal analysis, Investigation, Methodology, Software, Writing – original draft, Writing – review & editing

Affiliations Department of Internal Medicine, College of Medicine, Seoul National University, Seoul, Korea, Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea

Ara Cho

Contributed equally to this work with: Wencheng Jin, Ara Cho

Roles Data curation, Formal analysis, Investigation, Methodology, Software

Affiliation Translational Medicine Major, Seoul National University College of Medicine, Seoul, Korea

Bogyeong Cho

Roles Data curation, Formal analysis, Investigation, Visualization, Writing – review & editing

Affiliation Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea

Nayeon Shin

Roles Data curation, Formal analysis, Methodology

Affiliation Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea

Yun Kyu Oh

Roles Supervision

Affiliations Department of Internal Medicine, College of Medicine, Seoul National University, Seoul, Korea, Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea

Chun Soo Lim

Roles Supervision

Affiliations Department of Internal Medicine, College of Medicine, Seoul National University, Seoul, Korea, Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea

Jung Pyo Lee

Roles Investigation, Methodology, Resources, Supervision

Affiliations Department of Internal Medicine, College of Medicine, Seoul National University, Seoul, Korea, Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea

Jeonghwan Lee

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Software, Supervision, Visualization, Writing – review & editing

jeonghwan@snu.ac.kr

Affiliations Department of Internal Medicine, College of Medicine, Seoul National University, Seoul, Korea, Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea

Competing Interests

Medvill Korea provided MN705 and other natural substances used in this study free of charge for academic research purposes. However, the company did not participate in the study design, data analysis, or manuscript preparation. Additionally, we declare that there are currently no patents, products in development, or marketed products associated with this research. We confirm that these competing interests do not alter our adherence to PLOS One policies on sharing data and materials.