About the Authors

Austin M. Gabel

Contributed equally to this work with: Austin M. Gabel, Edie I. Crosse

Roles Conceptualization, Investigation, Writing – original draft

Affiliations Computational Biology Program, Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America, Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America, Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America, Medical Scientist Training Program, University of Washington, Seattle, Washington, United States of America

Edie I. Crosse

Contributed equally to this work with: Austin M. Gabel, Edie I. Crosse

Roles Data curation, Formal analysis, Visualization, Writing – original draft

Affiliations Computational Biology Program, Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America, Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America

Andrea E. Belleville

Roles Investigation

Affiliations Computational Biology Program, Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America, Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America, Medical Scientist Training Program, University of Washington, Seattle, Washington, United States of America, Molecular and Cellular Biology Program, University of Washington, Seattle, Washington, United States of America

Simon J. Hogg

Roles Investigation

Affiliation Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America

Siegen A. McKellar

Roles Investigation

Affiliations Computational Biology Program, Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America, Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America, Medical Scientist Training Program, University of Washington, Seattle, Washington, United States of America, Molecular and Cellular Biology Program, University of Washington, Seattle, Washington, United States of America

Omar Abdel-Wahab

Roles Conceptualization

‡ Co-senior authors

Affiliation Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America

James D. Thomas

Roles Conceptualization, Formal analysis, Investigation

‡ Co-senior authors

Affiliations Computational Biology Program, Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America, Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America

Robert K. Bradley

Roles Conceptualization, Funding acquisition, Writing – review & editing

rbradley@fredhutch.org

‡ Co-senior authors

Affiliations Computational Biology Program, Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America, Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America, Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

Competing Interests

RKB is a founder and scientific advisor of Codify Therapeutics and Synthesize Bio and holds equity in both companies. OA-W is a founder and scientific advisor of Codify Therapeutics and holds equity in this company. RKB and OA-W have received research funding from Codify Therapeutics unrelated to the current work. OA-W has served as a consultant for Foundation Medicine Inc., Merck, Prelude Therapeutics, Amphista Therapeutics, MagnetBio, and Janssen, and is on the Scientific Advisory Board of Envisagenics Inc., Harmonic Discovery Inc., and Pfizer Boulder; OA-W has received prior research funding from H3B Biomedicine, Nurix Therapeutics, Minovia Therapeutics, and LOXO Oncology unrelated to the current manuscript. This does not alter our adherence to PLoS One policies on sharing data and materials. The remaining authors declare no competing interests.