About the Authors

Takuro Okai

Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

takuro.okai@takeda.com

Affiliation Neuroscience Drug Discovery Unit, Research, Takeda Pharmaceutical Company Limited, Fujisawa, Japan

Sho Sato

Roles Formal analysis, Methodology, Writing – review & editing

Affiliation Center of Excellence for Drug Metabolism, Pharmacokinetics and Modeling, Preclinical and Translational Sciences, Research, Takeda Pharmaceutical Company Limited, Fujisawa, Japan

Mugdha Deshpande

Roles Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Takeda Development Center Americas, Cambridge, Massachusetts, United States of America

Shin-ichi Matsumoto

Roles Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

Affiliation Center of Excellence for Drug Metabolism, Pharmacokinetics and Modeling, Preclinical and Translational Sciences, Research, Takeda Pharmaceutical Company Limited, Fujisawa, Japan

Miyu Nakayama

Roles Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

Affiliation Center of Excellence for Drug Metabolism, Pharmacokinetics and Modeling, Preclinical and Translational Sciences, Research, Takeda Pharmaceutical Company Limited, Fujisawa, Japan

Syunsuke Yamamoto

Roles Formal analysis, Methodology, Writing – review & editing

Affiliation Center of Excellence for Drug Metabolism, Pharmacokinetics and Modeling, Preclinical and Translational Sciences, Research, Takeda Pharmaceutical Company Limited, Fujisawa, Japan

Bettina Strack-Logue

Roles Conceptualization, Writing – original draft, Writing – review & editing

Affiliation Neuroscience Drug Discovery Unit, Research, Takeda Development Center Americas, Inc, Cambridge, Massachusetts, United States of America

Takeshi Hioki

Roles Conceptualization, Supervision, Writing – review & editing

Affiliation Neuroscience Drug Discovery Unit, Research, Takeda Pharmaceutical Company Limited, Fujisawa, Japan

Maiko Tanaka

Roles Conceptualization, Supervision, Writing – review & editing

Affiliation Neuroscience Drug Discovery Unit, Research, Takeda Pharmaceutical Company Limited, Fujisawa, Japan

Gabriele Proetzel

Roles Conceptualization, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

Affiliation Neuroscience Drug Discovery Unit, Research, Takeda Development Center Americas, Inc, Cambridge, Massachusetts, United States of America

Competing Interests

I have read the journal's policy and the authors of this manuscript have the following competing interests: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: T. Okai, S. Sato, S. Matsumoto, M. Nakayama, S. Yamamoto, T. Hioki, and M. Tanaka report on a relationship with Takeda Pharmaceutical Company Limited that includes employment and non-financial support. M. Deshpande, B. Strack-Logue and G. Proetzel report on a relationship with Takeda Development Center Americas that includes employment and non-financial support.