Elucidating the structural dynamics induced by active site mutations in 3C protease of foot-and-mouth disease virus

Sthitaprajna Sahoo; Hak-Kyo Lee; Donghyun Shin

doi:10.1371/journal.pone.0321079

Loading metrics

Open Access

Peer-reviewed

Research Article

Elucidating the structural dynamics induced by active site mutations in 3C protease of foot-and-mouth disease virus

Sthitaprajna Sahoo,

Roles Conceptualization, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation Department of Agricultural Convergence Technology, Jeonbuk National University, Jeonju, Republic of Korea
⨯
Hak-Kyo Lee ,

Roles Supervision, Writing – review & editing

* E-mail: breedlee@jbnu.ac.kr (HL); sdh1214@gmail.com (DS)

Affiliations Department of Agricultural Convergence Technology, Jeonbuk National University, Jeonju, Republic of Korea, Department of Animal Biotechnology, Jeonbuk National University, Jeonju, Republic of Korea
⨯
Donghyun Shin

Roles Conceptualization, Supervision, Writing – review & editing

* E-mail: breedlee@jbnu.ac.kr (HL); sdh1214@gmail.com (DS)

Affiliation Department of Agricultural Convergence Technology, Jeonbuk National University, Jeonju, Republic of Korea

https://orcid.org/0000-0002-0819-0553

⨯

Elucidating the structural dynamics induced by active site mutations in 3C protease of foot-and-mouth disease virus

Sthitaprajna Sahoo,
Hak-Kyo Lee,
Donghyun Shin

Published: April 21, 2025
https://doi.org/10.1371/journal.pone.0321079

About the Authors

Sthitaprajna Sahoo

Roles Conceptualization, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation Department of Agricultural Convergence Technology, Jeonbuk National University, Jeonju, Republic of Korea

Hak-Kyo Lee

Roles Supervision, Writing – review & editing

* E-mail: breedlee@jbnu.ac.kr (HL); sdh1214@gmail.com (DS)

Affiliations Department of Agricultural Convergence Technology, Jeonbuk National University, Jeonju, Republic of Korea, Department of Animal Biotechnology, Jeonbuk National University, Jeonju, Republic of Korea

Donghyun Shin

Roles Conceptualization, Supervision, Writing – review & editing

* E-mail: breedlee@jbnu.ac.kr (HL); sdh1214@gmail.com (DS)

Affiliation Department of Agricultural Convergence Technology, Jeonbuk National University, Jeonju, Republic of Korea

https://orcid.org/0000-0002-0819-0553

Competing Interests

The authors have declared that no competing interests exist.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Foot and mouth disease
Is the Subject Area "Foot and mouth disease" applicable to this article?

Thanks for your feedback.
Protein structure
Is the Subject Area "Protein structure" applicable to this article?

Thanks for your feedback.
Amino acid analysis
Is the Subject Area "Amino acid analysis" applicable to this article?

Thanks for your feedback.
Biochemical simulations
Is the Subject Area "Biochemical simulations" applicable to this article?

Thanks for your feedback.
Proteases
Is the Subject Area "Proteases" applicable to this article?

Thanks for your feedback.
Protein structure prediction
Is the Subject Area "Protein structure prediction" applicable to this article?

Thanks for your feedback.
Principal component analysis
Is the Subject Area "Principal component analysis" applicable to this article?

Thanks for your feedback.
Enzyme structure
Is the Subject Area "Enzyme structure" applicable to this article?

Thanks for your feedback.