Multi-organ gene expression analysis and network modeling reveal regulatory control cascades during the development of hypertension in female spontaneously hypertensive rat

Eden Hornung; Sirisha Achanta; Alison Moss; James S. Schwaber; Rajanikanth Vadigepalli

doi:10.1371/journal.pone.0313252

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Open Access

Peer-reviewed

Research Article

Multi-organ gene expression analysis and network modeling reveal regulatory control cascades during the development of hypertension in female spontaneously hypertensive rat

Eden Hornung ,

Contributed equally to this work with: Eden Hornung, Sirisha Achanta

Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Pathology and Genomic Medicine, Daniel Baugh Institute for Functional Genomics and Computational Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
⨯
Sirisha Achanta ,

Contributed equally to this work with: Eden Hornung, Sirisha Achanta

Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

Affiliation Department of Pathology and Genomic Medicine, Daniel Baugh Institute for Functional Genomics and Computational Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
⨯
Alison Moss,

Roles Data curation, Formal analysis, Methodology, Software, Visualization, Writing – original draft

Affiliation Department of Pathology and Genomic Medicine, Daniel Baugh Institute for Functional Genomics and Computational Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
⨯
James S. Schwaber ,

Roles Conceptualization, Funding acquisition, Methodology, Writing – review & editing

* E-mail: rajanikanth.vadigepalli@jefferson.edu (RV); james.schwaber@jefferson.edu (JSS)

Affiliation Department of Pathology and Genomic Medicine, Daniel Baugh Institute for Functional Genomics and Computational Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
⨯
Rajanikanth Vadigepalli

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Visualization, Writing – review & editing

* E-mail: rajanikanth.vadigepalli@jefferson.edu (RV); james.schwaber@jefferson.edu (JSS)

Affiliation Department of Pathology and Genomic Medicine, Daniel Baugh Institute for Functional Genomics and Computational Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

https://orcid.org/0000-0002-8405-1037

⨯

Multi-organ gene expression analysis and network modeling reveal regulatory control cascades during the development of hypertension in female spontaneously hypertensive rat

Eden Hornung,
Sirisha Achanta,
Alison Moss,
James S. Schwaber,
Rajanikanth Vadigepalli

Published: November 8, 2024
https://doi.org/10.1371/journal.pone.0313252

About the Authors

Eden Hornung

Contributed equally to this work with: Eden Hornung, Sirisha Achanta

Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Pathology and Genomic Medicine, Daniel Baugh Institute for Functional Genomics and Computational Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

Sirisha Achanta

Contributed equally to this work with: Eden Hornung, Sirisha Achanta

Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

Alison Moss

Roles Data curation, Formal analysis, Methodology, Software, Visualization, Writing – original draft

James S. Schwaber

Roles Conceptualization, Funding acquisition, Methodology, Writing – review & editing

* E-mail: rajanikanth.vadigepalli@jefferson.edu (RV); james.schwaber@jefferson.edu (JSS)

Rajanikanth Vadigepalli

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Visualization, Writing – review & editing

* E-mail: rajanikanth.vadigepalli@jefferson.edu (RV); james.schwaber@jefferson.edu (JSS)

https://orcid.org/0000-0002-8405-1037

Competing Interests

The authors have declared that no competing interests exist.

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Kidneys
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Adrenal glands
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Gene expression
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Gene regulation
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Hypertension
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Inflammation
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Brainstem
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Genetic networks
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