https://orcid.org/0000-0002-5035-6828
About the Authors
- Christopher A. Smith
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Contributed equally to this work with: Christopher A. Smith, Elisabeth A. A. O’Flaherty
Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing
Affiliation Institute of Metabolic Science, Metabolic Research Laboratories, Addenbrooke’s Hospital, Cambridge, United Kingdom
- Elisabeth A. A. O’Flaherty
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Contributed equally to this work with: Christopher A. Smith, Elisabeth A. A. O’Flaherty
Roles Investigation, Writing – review & editing
Affiliation Institute of Metabolic Science, Metabolic Research Laboratories, Addenbrooke’s Hospital, Cambridge, United Kingdom
- Nunzio Guccio
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Roles Investigation, Writing – review & editing
Affiliation Institute of Metabolic Science, Metabolic Research Laboratories, Addenbrooke’s Hospital, Cambridge, United Kingdom
- Austin Punnoose
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Roles Investigation, Methodology
Affiliation Institute of Metabolic Science, Metabolic Research Laboratories, Addenbrooke’s Hospital, Cambridge, United Kingdom
- Tamana Darwish
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Roles Investigation, Writing – review & editing
Affiliation Institute of Metabolic Science, Metabolic Research Laboratories, Addenbrooke’s Hospital, Cambridge, United Kingdom
- Jo E. Lewis
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Roles Investigation, Methodology, Writing – review & editing
Affiliation Institute of Metabolic Science, Metabolic Research Laboratories, Addenbrooke’s Hospital, Cambridge, United Kingdom
- Rachel E. Foreman
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Roles Investigation, Methodology, Writing – review & editing
Current address: Integrated Bioanalysis, Clinical Pharmacology & Safety Sciences, AstraZeneca, Biomedical Campus, Cambridge, United Kingdom
Affiliation Institute of Metabolic Science, Metabolic Research Laboratories, Addenbrooke’s Hospital, Cambridge, United Kingdom
- Joyce Li
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Roles Resources, Writing – review & editing
Affiliation Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
- Richard G. Kay
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Roles Methodology, Supervision, Writing – review & editing
Affiliation Institute of Metabolic Science, Metabolic Research Laboratories, Addenbrooke’s Hospital, Cambridge, United Kingdom
- Alice E. Adriaenssens
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Roles Investigation, Methodology, Supervision, Writing – review & editing
Current address: Division of Biosciences, University College London, London, United Kingdom
Affiliation Institute of Metabolic Science, Metabolic Research Laboratories, Addenbrooke’s Hospital, Cambridge, United Kingdom
- Frank Reimann
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Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing
* E-mail: fr222@cam.ac.uk (FR); fmg23@cam.ac.uk (FMG)
¶‡ FR and FMG are joint senior authors on this work.
Affiliation Institute of Metabolic Science, Metabolic Research Laboratories, Addenbrooke’s Hospital, Cambridge, United Kingdom
- Fiona M. Gribble
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Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing
* E-mail: fr222@cam.ac.uk (FR); fmg23@cam.ac.uk (FMG)
¶‡ FR and FMG are joint senior authors on this work.
Affiliation Institute of Metabolic Science, Metabolic Research Laboratories, Addenbrooke’s Hospital, Cambridge, United Kingdom
Competing Interests
“FMG and FR have received funding for other projects from AstraZeneca and Eli Lilly. LGC provided partial salary support for REF, but was not otherwise involved with this study. Since completing the work, REF moved to work for AstraZeneca which has had no involvement with the study. This does not alter our adherence to PLOS ONE policies on sharing data and materials.”