About the Authors

Tu Anh Nguyen

Roles Investigation, Writing – original draft

Affiliation Department of Biomedical Science and Center for Bio-Nanomaterials, Daegu University, Gyeongsan, South Korea

Trang Hoang

Roles Investigation

Affiliation Department of Biomedical Science and Center for Bio-Nanomaterials, Daegu University, Gyeongsan, South Korea

Thu-Thuy Nguyen

Roles Investigation

Affiliation Department of Biomedical Science and Center for Bio-Nanomaterials, Daegu University, Gyeongsan, South Korea

ChanSu Jeong

Roles Investigation

Affiliation Department of Biomedical Science and Center for Bio-Nanomaterials, Daegu University, Gyeongsan, South Korea

Trang Van Tran

Roles Investigation

Affiliation Department of Biomedical Science and Center for Bio-Nanomaterials, Daegu University, Gyeongsan, South Korea

Mal-Gi Choi

Roles Writing – review & editing

Affiliation Odysgen Inc., Daegu, South Korea

ChangWoo Lee

Roles Conceptualization, Writing – original draft, Writing – review & editing

leec@daegu.ac.kr

Affiliation Department of Biomedical Science and Center for Bio-Nanomaterials, Daegu University, Gyeongsan, South Korea

Competing Interests

M.G.C. is an employee of and holds shares in Odysgen Inc. A patent application titled "NEUTRAL pH-ACTIVE VARIANTS OF HYALURONIDASE HYAL1" has been submitted in Korea and through the PCT system by Odysgen Inc., based on the findings of this study (International publication number: WO2024005502A1). This does not alter our adherence to PLOS ONE policies on sharing data and materials