About the Authors

Naoya Ishibashi

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

n.ishibashi@teijin.co.jp

Affiliation Bio-Medical Engineering Group, Drug Discovery Laboratory, Teijin Institute for Bio-Medical Research, Teijin Pharma Ltd., Tokyo, Japan

Tomoyuki Uchiyama

Roles Writing – review & editing

Affiliations Department of Neurology, School of Medicine, International University of Health and Welfare, Chiba, Japan, Department of Neurology, International University of Health and Welfare Shioya Hospital, Tochigi, Japan, Department of Neurology, School of Medicine, Chiba University, Chiba, Japan

Shinichi Tao

Roles Supervision

Affiliation Bio-Medical Engineering Group, Drug Discovery Laboratory, Teijin Institute for Bio-Medical Research, Teijin Pharma Ltd., Tokyo, Japan

Competing Interests

I have read the journal’s policy and the authors of this manuscript have the following competing interests: [International University of Health and Welfare received the grant support from Teijin Pharma Limited for another research with Dr. Uchiyama.] This does not alter our adherence to PLOS ONE policies on sharing data and materials.