About the Authors

Karel H. van der Pol

Roles Data curation, Formal analysis, Methodology, Visualization, Writing – original draft, Writing – review & editing

karel.vanderpol@radboudumc.nl

Affiliations Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands, Department of Pharmacology and Toxicology, Radboud University Medical Center, Nijmegen, The Netherlands

Jan Koenderink

Roles Investigation, Methodology, Resources, Validation, Writing – review & editing

Affiliation Department of Pharmacology and Toxicology, Radboud University Medical Center, Nijmegen, The Netherlands

Jeroen J. M. W. van den Heuvel

Roles Investigation, Resources, Validation, Writing – review & editing

Affiliation Department of Pharmacology and Toxicology, Radboud University Medical Center, Nijmegen, The Netherlands

Petra van den Broek

Roles Investigation, Methodology, Resources, Validation, Writing – review & editing

Affiliation Department of Pharmacology and Toxicology, Radboud University Medical Center, Nijmegen, The Netherlands

Janny Peters

Roles Investigation, Validation, Writing – review & editing

Affiliation Department of Pharmacology and Toxicology, Radboud University Medical Center, Nijmegen, The Netherlands

Imke D. W. van Bunningen

Roles Investigation, Validation, Writing – review & editing

Affiliation Department of Pharmacology and Toxicology, Radboud University Medical Center, Nijmegen, The Netherlands

Jeanne Pertijs

Roles Investigation, Validation, Writing – review & editing

Affiliation Department of Pharmacology and Toxicology, Radboud University Medical Center, Nijmegen, The Netherlands

Frans G. M. Russel

Roles Supervision, Writing – review & editing

Affiliation Department of Pharmacology and Toxicology, Radboud University Medical Center, Nijmegen, The Netherlands

Jim Koldenhof

Roles Investigation, Validation, Writing – review & editing

Affiliation Applied Stem Cell Technologies, University of Twente, Enschede, The Netherlands

Wim J. Morshuis

Roles Resources, Writing – review & editing

Affiliation Department of Cardio-thoracic Surgery, Radboud University Medical Center, Nijmegen, The Netherlands

Joris van Drongelen

Roles Resources, Writing – review & editing

Affiliation Department of Obstetrics and Gynaecology, Radboud University Medical Center, Nijmegen, The Netherlands

Tom J. J. Schirris

Roles Investigation, Methodology, Resources, Validation, Writing – review & editing

Affiliation Department of Pharmacology and Toxicology, Radboud University Medical Center, Nijmegen, The Netherlands

Andries van der Meer

Roles Conceptualization, Methodology, Project administration, Supervision, Writing – review & editing

Affiliation Applied Stem Cell Technologies, University of Twente, Enschede, The Netherlands

Gerard A. Rongen

Roles Conceptualization, Methodology, Project administration, Supervision, Writing – review & editing

Affiliations Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands, Department of Pharmacology and Toxicology, Radboud University Medical Center, Nijmegen, The Netherlands

Competing Interests

I have read the journal’s policy and the authors of this manuscript have the following competing interests: FR is a member of the Dutch Medicines Evaluation Board. The other authors have declared that no competing interests exist. This does not alter our adherence to PLOS ONE policies on sharing data and materials.