About the Authors

Jonathan M. Alektiar

Contributed equally to this work with: Jonathan M. Alektiar, Mengrou Shan

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States of America

Mengrou Shan

Contributed equally to this work with: Jonathan M. Alektiar, Mengrou Shan

Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – review & editing

Affiliation Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States of America

Megan D. Radyk

Roles Investigation, Methodology, Project administration

Affiliation Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States of America

Li Zhang

Roles Data curation, Formal analysis, Investigation, Writing – review & editing

Affiliation Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States of America

Christopher J. Halbrook

Roles Data curation, Formal analysis, Writing – review & editing

Affiliation Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States of America

Lin Lin

Roles Investigation, Writing – review & editing

Affiliation Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States of America

Carlos Espinoza

Roles Investigation, Methodology

Affiliation Department of Surgery, University of Michigan, Ann Arbor, Michigan, United States of America

Ivan F. Mier

Roles Data curation, Investigation, Methodology

Affiliation Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

Brooke L. Lavoie

Roles Investigation

Affiliation Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States of America

Lucie Salvatore

Roles Investigation, Methodology, Writing – review & editing

Affiliation Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States of America

Marina Pasca di Magliano

Roles Project administration, Supervision

Affiliations Department of Surgery, University of Michigan, Ann Arbor, Michigan, United States of America, Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan, United States of America

Lewis C. Cantley

Roles Conceptualization, Project administration, Resources, Supervision, Writing – review & editing

Affiliations Department of Cancer Biology, Dana Farber Cancer Center, Boston, Massachusetts, United States of America, Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America

Jacob L. Mueller

Roles Conceptualization, Investigation, Methodology, Project administration, Resources, Writing – review & editing

Affiliation Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

Costas A. Lyssiotis

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

clyssiot@med.umich.edu

Affiliations Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States of America, Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan, United States of America, Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

Competing Interests

L.C.C. and C.A.L. are inventors on patents pertaining to Kras regulated metabolic pathways, redox control pathways in pancreatic cancer, and targeting GOT1 or ME1 as a therapeutic approach (US Patent No: 2015126580-A1, 05/07/2015; US Patent No: 20190136238, 05/09/2019; International Patent No: WO2013177426-A2, 04/23/2015). L.C.C. owns equity in, receives compensation from, and serves on the Scientific Advisory Boards of Faeth Therapeutics, Agios Pharmaceuticals, Volastra Therapeutics, and Larkspur Biosciences. L.C.C.’s laboratory has previously received financial support from Petra Pharmaceuticals. Agios Pharmaceuticals is identifying metabolic pathways of cancer cells and developing drugs to inhibit such enzymes to disrupt tumor cell growth and survival. In the last 3 years, C.A.L. has received consulting fees from Astellas Pharmaceuticals, Odyssey Therapeutics, Third Rock Ventures, and T-Knife Therapeutics. This does not alter our adherence to PLOS ONE policies on sharing data and materials.