About the Authors

Naveen Garg

Roles Investigation, Writing – review & editing

Affiliation Centricity Research-Montreal, Point-Claire, Québec, Canada

Guy Tellier

Roles Investigation, Writing – review & editing

Affiliation Centricity Research-Mirabel, Mirabel, Québec, Canada

Noah Vale

Roles Investigation, Writing – review & editing

Affiliation Centricity Research-Toronto, Toronto, Ontario, Canada

Jon Kluge

Roles Data curation, Project administration, Supervision, Writing – review & editing

Affiliation Research and Development, Vaxess Technologies, Cambridge, Massachusetts, United States of America

Jonathan L. Portman

Roles Data curation, Writing – review & editing

Affiliation Research and Development, Vaxess Technologies, Cambridge, Massachusetts, United States of America

Anna Markowska

Roles Data curation, Writing – review & editing

Affiliation Research and Development, Vaxess Technologies, Cambridge, Massachusetts, United States of America

Lynda Tussey

Roles Conceptualization, Formal analysis, Project administration, Writing – original draft, Writing – review & editing

lynda@vaxess.com

Affiliation Development and MAP Production, Vaxess Technologies, Woburn, Massachusetts, United States of America

Competing Interests

Jon Kluge, Jonathan L. Portman, Anna Markowska and Lynda Tussey are employees of the clinical trial sponsor Vaxess Technologies. Naveen Garg, Guy Tellier and Noah Vale are employees of Centricity Research, the clinical research organization responsible for conducting the VX103-01 clinical trial. All Vaxess related patent information is included below. These competing interests do not impact the authors adherence to PLOS ONE policies and data sharing. Country Application No. Publication No Application Title US 17/714025 US-2022-0339416-A1 SILK FIBROIN-BASED MICRONEEDLES AND USES THEREOF WO PCT/US2020/055139 WO 2021/072313 SILK FIBROIN-BASED MICRONEEDLES AND USES THEREOF AU 2020364146 SILK FIBROIN-BASED MICRONEEDLES AND USES THEREOF CA 3156676 3156676 SILK FIBROIN-BASED MICRONEEDLES AND USES THEREOF CN 202080071018.4 114728154 SILK FIBROIN-BASED MICRONEEDLES AND USES THEREOF EP 20874211.4 4041330 SILK FIBROIN-BASED MICRONEEDLES AND USES THEREOF JP 2022-521636 2022-551910 SILK FIBROIN-BASED MICRONEEDLES AND USES THEREOF KR 10-2022-7014919 10-2022-0093120 SILK FIBROIN-BASED MICRONEEDLES AND USES THEREOF US 17/958148 US-2023-0190911-A1 VACCINE FORMULATIONS WITH INCREASED STABILITY WO PCT/US2017/052301 WO 2018/053524 VACCINE FORMULATIONS WITH INCREASED STABILITY AU 2017327009 2017327009 VACCINE FORMULATIONS WITH INCREASED STABILITY CA 3037337 3037337 VACCINE FORMULATIONS WITH INCREASED STABILITY EP 17778047.5 3532093 VACCINE FORMULATIONS WITH INCREASED STABILITY US 17/157451 US-2021-0283597-A1 POLYMER-BASED BIOSPECIMEN COLLECTION DEVICES AND USES THEREOF WO PCT/US2019/043727 WO 2020/023906 POLYMER-BASED BIOSPECIMEN COLLECTION DEVICES AND USES THEREOF EP 19761984.4 3830576 POLYMER-BASED BIOSPECIMEN COLLECTION DEVICES AND USES THEREOF US 17/044439 US-2021-0085598-A1 MICRONEEDLE COMPRISING SILK FIBROIN APPLIED TO A DISSOLVABLE BASE WO PCT/US2019/025467 WO 2019/195350 MICRONEEDLE COMPRISING SILK FIBROIN APPLIED TO A DISSOLVABLE BASE AU 2019247655 MICRONEEDLE COMPRISING SILK FIBROIN APPLIED TO A DISSOLVABLE BASE CA 3096036 3096036 MICRONEEDLE COMPRISING SILK FIBROIN APPLIED TO A DISSOLVABLE BASE EP 19718034.2 3773477 MICRONEEDLE COMPRISING SILK FIBROIN APPLIED TO A DISSOLVABLE BASE WO PCT/US2023/026036 WO 2023/250117 APPLICATOR FOR MEDICAMENT PATCH US 17/991525 US-2023-0270842-A1 COMPOSITIONS AND DEVICES FOR VACCINE RELEASE AND USES THEREOF WO PCT/US2021/033776 WO 2021/237174 COMPOSITIONS AND DEVICES FOR VACCINE RELEASE AND USES THEREOF AU 2021276000 COMPOSITIONS AND DEVICES FOR VACCINE RELEASE AND USES THEREOF CA 3183930 3183930 COMPOSITIONS AND DEVICES FOR VACCINE RELEASE AND USES THEREOF CN 202180061194.4 CN116406285A COMPOSITIONS AND DEVICES FOR VACCINE RELEASE AND USES THEREOF EP 21809075.1 4153139 COMPOSITIONS AND DEVICES FOR VACCINE RELEASE AND USES THEREOF JP 2022-571231 2023-527175 COMPOSITIONS AND DEVICES FOR VACCINE RELEASE AND USES THEREOF KR 10-2022-7044731 COMPOSITIONS AND DEVICES FOR VACCINE RELEASE AND USES THEREOF US 18/563337 MICRONEEDLE VACCINE AGAINST SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 (SARS-COV-2)