About the Authors

Felix Lindberg

Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

‡ FL and NO are contributed equally to this work as first authors.

Affiliation Division of Cardiology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden

Natanael Øigaard

Roles Formal analysis, Investigation, Writing – original draft, Writing – review & editing

‡ FL and NO are contributed equally to this work as first authors.

Affiliation Division of Cardiology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden

Marco Metra

Roles Writing – review & editing

Affiliation Cardiology, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, Cardiothoracic Department, Civil Hospitals, University of Brescia, Brescia, Italy

Giuseppe M. C. Rosano

Roles Writing – review & editing

Affiliations Cardiovascular Clinical Academic Group, Molecular and Clinical Research Institute, St George’s University Hospital, London, United Kingdom, Cardiology, San Raffaele Cassino Hospital, Cassino, Italy

Ulf Dahlström

Roles Writing – review & editing

Affiliation Department of Cardiology and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden

Peter Mol

Roles Writing – review & editing

Affiliation Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

Camilla Hage

Roles Writing – review & editing

Affiliations Division of Cardiology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, Heart and Vascular and Neuro Theme, Karolinska University Hospital, Stockholm, Sweden

Lars H. Lund

Roles Writing – review & editing

Affiliations Division of Cardiology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, Heart and Vascular and Neuro Theme, Karolinska University Hospital, Stockholm, Sweden

Gianluigi Savarese

Roles Conceptualization, Data curation, Funding acquisition, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

Gianluigi.savarese@ki.se

Affiliations Division of Cardiology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, Heart and Vascular and Neuro Theme, Karolinska University Hospital, Stockholm, Sweden

Competing Interests

FL has no conflicts of interest to declare. NØ has no conflicts of interest to declare. MM reports grants and other from Amgen, Abbott Vascular, Edwards Therapeutics, Servier, WindTree Therapeutics, Actelion, Livanova, Vifor Pharma. GR reports no conflicts of interest. UD reports research grants from AstraZeneca, Boehringer Ingelheim, Pfizer, Vifor, Boston Scientific, Roche Diagnostics and honoraria/consultancies from Amgen, Pfizer and AstraZeneca all outside the present manuscript. PM has no conflicts of interest to declare. CH none related to the present work; unrelated to the present work: consulting fees from Novartis, Roche Diagnostics, and AnaCardio; speaker fees from Novartis and Merck Sharp & Dohme. LHL none related to the present work; unrelated to the present work: grants, consulting, honoraria: Abbot, Alleviant, AstraZeneca, Bayer, Biopeutics, Boehringer Ingelheim, Edwards, FineHeart, MedScape/WebMD, Merck/MSD, Novartis, Novo Nordisk, OrionPharma, Pharmacosmos, Radcliffe Cardiology, Roche, Sanofi, Servier, Translational Medicines Academy, Vifor; Stock ownership: AnaCardio. GS received financial support from Cytokinetics for performing this investigator-initiated study. GS reports grants and personal fees from Vifor, personal fees and grants from Boehringer Ingelheim, grants and personal fees from AstraZeneca, personal fees from Roche, grants and personal fees from Servier, grants and personal fees from Novartis, grants and personal fees from Cytokinetics, personal fees from Medtronic, grants from Boston Scientific, grants and personal fees from Pharmacosmos, grants from Merck, grants from Bayer, personal fees from INTAS, personal fees from Abbott, outside the submitted work. This does not alter our adherence to PLOS ONE policies on sharing data and materials