About the Authors

Shalini Pullarkat

Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America

Graeme Black

Roles Resources

Affiliation Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America

Marie Bleakley

Roles Resources, Writing – review & editing

Affiliations Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America, Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America, Department of Pediatrics, University of Washington, Seattle, Washington, United States of America, Program in Immunology, University of Washington, Seattle, Washington, United States of America

Denise Buenrostro

Roles Resources

Affiliations Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America, Program in Immunology, University of Washington, Seattle, Washington, United States of America

Aude G. Chapuis

Roles Resources

Affiliations Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America, Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America, Program in Immunology, University of Washington, Seattle, Washington, United States of America, Department of Medicine, Division of Hematology and Oncology, University of Washington, Seattle, Washington, United States of America

Alexandre V. Hirayama

Roles Conceptualization, Resources

Affiliations Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America, Department of Medicine, Division of Hematology and Oncology, University of Washington, Seattle, Washington, United States of America

Carla A. Jaeger-Ruckstuhl

Roles Resources, Writing – review & editing

Affiliation Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America

Erik L. Kimble

Roles Conceptualization, Methodology, Resources, Writing – review & editing

Affiliations Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America, Department of Medicine, Division of Hematology and Oncology, University of Washington, Seattle, Washington, United States of America

Bo M. Lee

Roles Resources

Affiliation Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America

David G. Maloney

Roles Resources

Affiliations Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America, Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America, Department of Medicine, Division of Hematology and Oncology, University of Washington, Seattle, Washington, United States of America

Jerald Radich

Roles Resources, Supervision, Writing – review & editing

Affiliations Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America, Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America

Brandon W. Seaton

Roles Resources

Affiliation Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America

Jennifer M. Specht

Roles Funding acquisition, Resources, Writing – review & editing

Affiliations Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America, Department of Medicine, Division of Hematology and Oncology, University of Washington, Seattle, Washington, United States of America

Cameron J. Turtle

Roles Conceptualization, Methodology

Affiliations Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America, Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America, Department of Medicine, Division of Hematology and Oncology, University of Washington, Seattle, Washington, United States of America, Integrated Immunotherapy Research Center, Fred Hutchinson Cancer Center, Seattle, WA, United States of America

David W. Woolston

Roles Conceptualization, Methodology, Visualization, Writing – review & editing

Affiliation Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America

Jocelyn H. Wright

Roles Conceptualization, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

Affiliations Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America, Program in Immunology, University of Washington, Seattle, Washington, United States of America

Cecilia C. S. Yeung

Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – review & editing

cyeung5@uw.edu

Affiliations Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America, Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America, Department of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, Washington, United States of America

Competing Interests

All authors have read and understand PLOS ONE’s policies. The below commercial interests did not fund and have no association with the work performed in this study; therefore, this does not alter our adherence to PLOS ONE’s policies on sharing data and materials. The authors of this manuscript have the following competing interests: A.G.C. received research funding from Juno Therapeutics, a Bristol Myers Squibb Company. E.K. received research funding from Juno Therapeutics, a Bristol Myers Squibb Company. A.V.H. has received research funding from Juno Therapeutics, a Bristol Myers Squibb Company, and Nektar Therapeutics; has received honoraria from Bristol Myers Squibb. C.J.T. has received research funding from Juno Therapeutics/BMS, Nektar Therapeutics. C.J.T. is on the scientific advisory board for Caribou Biosciences, T-CURX, Myeloid Therapeutics, ArsenalBio, Cargo Therapeutics, Celgene/BMS Cell Therapy. C.J.T. is a DSMB member for Kyverna. C.J.T. ad hoc advisory boards/consulting (last 12 months) include: Nektar Therapeutics, Century Therapeutics, Legend Biotech, Allogene, Sobi, Syncopation Life Sciences, Prescient Therapeutics, Orna Therapeutics, IGM Biosciences, Abbvie. C.J.T. stock options: Eureka Therapeutics, Caribou Biosciences, Myeloid Therapeutics, ArsenalBio, Cargo Therapeutics. C.J.T. has the right to receive payment from Fred Hutch as an inventor on patents related to CAR T-cell therapy C.Y. has received research funding from Minerva, Lonza. C.Y. consults for TwinStrand Biosciences.