https://orcid.org/0000-0001-6073-4354
About the Authors
- Julien Pottecher
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Roles Conceptualization, Investigation, Methodology, Writing – review & editing
Affiliation Strasbourg University Hospital, UR3072, FHU OMICARE, FMTS, Strasbourg, France
- Francois Raffi
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Roles Investigation, Writing – review & editing
Affiliation Nantes Université, CHU Nantes, INSERM, Department of Infectious Diseases, CIC 1413, Nantes, France
- Martine Jandrot-Perrus
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Roles Conceptualization, Writing – review & editing
Affiliations UMR_S1148 INSERM/Paris University, Paris, France, Acticor-Biotech, Paris, France
- Sophie Binay
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Roles Conceptualization, Methodology, Writing – review & editing
Affiliation Acticor-Biotech, Paris, France
- Andrea Comenducci
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Roles Methodology, Writing – review & editing
Affiliation Acticor-Biotech, Paris, France
- Violaine Desort-Henin
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Roles Methodology, Writing – review & editing
Affiliation Acticor-Biotech, Paris, France
- Déborah François
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Roles Investigation, Writing – review & editing
Affiliation Acticor-Biotech, Paris, France
- Shahin Gharakhanian
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Roles Writing – review & editing
Affiliations Acticor-Biotech, Paris, France, Shahin Gharakhanian MD Consulting LLC, Cambridge Innovation Center, Cambridge, MA, United States of America
- Marilyn Labart
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Roles Project administration, Writing – review & editing
Affiliation Acticor-Biotech, Paris, France
- Adeline Meilhoc
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Roles Project administration, Writing – review & editing
Affiliation Acticor-Biotech, Paris, France
- Elie Toledano
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Roles Data curation, Writing – original draft, Writing – review & editing
* E-mail: elie.toledano@acticor-biotech.com
Affiliation Acticor-Biotech, Paris, France
- Yannick Pletan
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Roles Conceptualization, Formal analysis, Methodology, Writing – review & editing
Affiliation Acticor-Biotech, Paris, France
- Gilles Avenard
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Roles Conceptualization, Methodology, Validation, Writing – review & editing
¶‡ GA and VHS have contributed equally as Senior Authors on this work.
Affiliation Acticor-Biotech, Paris, France
- Victor H. Sato
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Roles Investigation, Methodology, Writing – review & editing
¶‡ GA and VHS have contributed equally as Senior Authors on this work.
Affiliation International Research Center, Hospital Alemão Oswaldo Cruz, Sao Paulo, Brazil
- the GARDEN Investigators
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¶GARDEN investigators list is provided in
S1 Appendix .
Competing Interests
The authors are declaring the following links of interest. JP was a part of GARDEN study scientific committee and worked as a consultant for Acticor Biotech, he also has link with AOP Orphan, Baxter, Edwards Lifseciences, Masimo, LFB, RDS and Takeda outside the scope of this work. FR has consultancy agreement with Astra Zeneca, Gilead, MSD, Roche and ViiV Healthcare. MJP is a scientific co-founder, consultant and shareholder of Acticor-Biotech. GA is a co-founder, CEO and shareholder of Acticor-Biotech. SB is the CSO and GM of Acticor Biotech. YP is the CMO and GM of Acticor Biotech as a consultant and has stock interest in Acticor Biotech. SB, AC, DF, ML, AM and ET are employees and have stock interest in Acticor Biotech. SG, VDH and GA are consultant for Acticor Biotech. Other authors have no links to disclose. Acticor Biotech is a commercial company currently developing GARDEN study drug, glenzocimab, and holds several related patents/rights. GARDEN study was an industry sponsored trial, and Acticor Biotech was involved, or provided support, for study design, data collection and analysis, decision to publish, and preparation of the manuscript. This does not alter our adherence to PLOS ONE policies on sharing data and materials.