About the Authors

Niklas Beschorner

Contributed equally to this work with: Niklas Beschorner, Paul Künzle

Roles Conceptualization, Data curation, Formal analysis, Investigation

Affiliations Leibniz-Institute of Virology (LIV), Hamburg, Germany, German Center for Infection Research (DZIF), Partner Site Hamburg–Lübeck–Borstel–Riems, Germany, PROVIREX Genome Editing Therapies GmbH, Hamburg, Germany

Paul Künzle

Contributed equally to this work with: Niklas Beschorner, Paul Künzle

Roles Conceptualization, Data curation, Formal analysis, Investigation

Affiliations Leibniz-Institute of Virology (LIV), Hamburg, Germany, German Center for Infection Research (DZIF), Partner Site Hamburg–Lübeck–Borstel–Riems, Germany

Maike Voges

Roles Data curation, Formal analysis, Investigation

Affiliations Leibniz-Institute of Virology (LIV), Hamburg, Germany, PROVIREX Genome Editing Therapies GmbH, Hamburg, Germany

Ilona Hauber

Roles Data curation, Investigation

Affiliations Leibniz-Institute of Virology (LIV), Hamburg, Germany, PROVIREX Genome Editing Therapies GmbH, Hamburg, Germany

Daniela Indenbirken

Roles Formal analysis, Investigation

Affiliations Leibniz-Institute of Virology (LIV), Hamburg, Germany, German Center for Infection Research (DZIF), Partner Site Hamburg–Lübeck–Borstel–Riems, Germany

Jacqueline Nakel

Roles Data curation, Investigation

Affiliations Leibniz-Institute of Virology (LIV), Hamburg, Germany, German Center for Infection Research (DZIF), Partner Site Hamburg–Lübeck–Borstel–Riems, Germany

Sanamjeet Virdi

Roles Formal analysis

Affiliations Leibniz-Institute of Virology (LIV), Hamburg, Germany, German Center for Infection Research (DZIF), Partner Site Hamburg–Lübeck–Borstel–Riems, Germany

Peter Bradtke

Roles Data curation, Formal analysis, Investigation

Affiliation Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Niels Christian Lory

Roles Data curation, Investigation

Affiliation Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Michael Rothe

Roles Investigation

Affiliation Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany

Maciej Paszkowski-Rogacz

Roles Data curation, Formal analysis, Investigation

Affiliation Medical Systems Biology, UCC, Medical Faculty Carl Gustav Carus, TU Dresden, Dresden, Germany

Frank Buchholz

Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Resources

Affiliations PROVIREX Genome Editing Therapies GmbH, Hamburg, Germany, Medical Systems Biology, UCC, Medical Faculty Carl Gustav Carus, TU Dresden, Dresden, Germany

Adam Grundhoff

Roles Formal analysis, Methodology

Affiliations Leibniz-Institute of Virology (LIV), Hamburg, Germany, German Center for Infection Research (DZIF), Partner Site Hamburg–Lübeck–Borstel–Riems, Germany

Axel Schambach

Roles Formal analysis, Resources

Affiliation Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany

Christian Thirion

Roles Resources

Affiliation SIRION Biotech GmbH, Gräfelfing, Germany

Hans-Willi Mittrücker

Roles Formal analysis, Methodology

Affiliations Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Julian Schulze zur Wiesch

Roles Formal analysis, Methodology

Affiliations German Center for Infection Research (DZIF), Partner Site Hamburg–Lübeck–Borstel–Riems, Germany, Infectious Diseases Unit, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Joachim Hauber

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Writing – original draft

Affiliations Leibniz-Institute of Virology (LIV), Hamburg, Germany, German Center for Infection Research (DZIF), Partner Site Hamburg–Lübeck–Borstel–Riems, Germany, PROVIREX Genome Editing Therapies GmbH, Hamburg, Germany

Jan Chemnitz

Roles Conceptualization, Formal analysis, Methodology, Project administration, Writing – original draft, Writing – review & editing

jan.chemnitz@provirex.de

Affiliations Leibniz-Institute of Virology (LIV), Hamburg, Germany, German Center for Infection Research (DZIF), Partner Site Hamburg–Lübeck–Borstel–Riems, Germany, PROVIREX Genome Editing Therapies GmbH, Hamburg, Germany

Competing Interests

The author’s have read the journal’s policy and have the following competing interests: Jan Chemnitz, Joachim Hauber, Frank Buchholz, Ilona Hauber, Niklas Beschorner and Maike Voges are founding partners of PROVIREX Genome Editing Therapies GmbH, which is commercially developing Brec1 technology. Niklas Beschorner and Maike Voges are full-time employees of PROVIREX Genome Editing Therapies GmbH since 2022, and Jan Chemnitz, Frank Buchholz, Joachim Hauber and Ilona Hauber are part-time employees. This does not alter our adherence to PLOS ONE policies on sharing data and materials. There are no patents, products in development or marketed products associated with this research to declare.