About the Authors

Kazushi Uneda

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

uneda@fmu.ac.jp

Affiliations Department of Kampo Medicine, Aizu Medical Center, Fukushima Medical University, Fukushima, Aizuwakamatsu, Japan, Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan

Yuki Kawai

Roles Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

Affiliation Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan

Akira Kaneko

Roles Writing – review & editing

Affiliation Department of Kampo Medicine, Aizu Medical Center, Fukushima Medical University, Fukushima, Aizuwakamatsu, Japan

Takumi Kayo

Roles Writing – review & editing

Affiliation Department of Kampo Medicine, Aizu Medical Center, Fukushima Medical University, Fukushima, Aizuwakamatsu, Japan

Shuichiro Akiba

Roles Writing – review & editing

Affiliation Department of Kampo Medicine, Aizu Medical Center, Fukushima Medical University, Fukushima, Aizuwakamatsu, Japan

Tomoaki Ishigami

Roles Writing – review & editing

Affiliation Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan

Hiromi Yoshida-Komiya

Roles Writing – review & editing

Affiliation Center for Gender-Specific Medicine, Fukushima Medical University, Fukushima, Japan

Masao Suzuki

Roles Writing – review & editing

Affiliation Department of Kampo Medicine, Aizu Medical Center, Fukushima Medical University, Fukushima, Aizuwakamatsu, Japan

Tadamichi Mitsuma

Roles Supervision, Writing – review & editing

Affiliation Department of Kampo Medicine, Aizu Medical Center, Fukushima Medical University, Fukushima, Aizuwakamatsu, Japan

Competing Interests

Kazushi Uneda, Akira Kaneko, and Tadamichi Mitsuma received research grant support from Tsumura & Co. Tadamichi Mitsuma previously received lecture fees from Tsumura & Co. and Kotaro Pharmaceutical Co., Ltd. The funders did not have any roles in study design, data collection, analysis, publishing decision, or manuscript preparation. This does not alter our adherence to the PLOS ONE policy on sharing data and materials. All authors contributed significantly to this article.