About the Authors

Jesyin Lai

Contributed equally to this work with: Jesyin Lai, Ping Zou

Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

jesyin.lai@stjude.org (JL); ranganatha.sitaram@stjude.org (RS)

Affiliation Department of Diagnostic Imaging, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

Ping Zou

Contributed equally to this work with: Jesyin Lai, Ping Zou

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Department of Diagnostic Imaging, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

Josue L. Dalboni da Rocha

Roles Conceptualization, Investigation, Methodology, Writing – review & editing

Affiliation Department of Diagnostic Imaging, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

Andrew M. Heitzer

Roles Conceptualization, Methodology, Writing – review & editing

Affiliation Department of Psychology and Biobehavioral Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

Tushar Patni

Roles Formal analysis, Writing – review & editing

Affiliation Department of Biostatistics, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

Yimei Li

Roles Formal analysis, Writing – review & editing

Affiliation Department of Biostatistics, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

Matthew A. Scoggins

Roles Conceptualization, Methodology, Writing – review & editing

Affiliation Department of Psychology and Biobehavioral Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

Akshay Sharma

Roles Conceptualization, Methodology, Writing – review & editing

Affiliation Department of Bone Marrow Transplantation & Cellular Therapy, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

Winfred C. Wang

Roles Conceptualization, Methodology, Writing – review & editing

Affiliation Department of Hematology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

Kathleen J. Helton

Roles Conceptualization, Funding acquisition, Project administration, Writing – review & editing

Affiliation Department of Diagnostic Imaging, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

Ranganatha Sitaram

Roles Conceptualization, Project administration, Supervision, Writing – review & editing

jesyin.lai@stjude.org (JL); ranganatha.sitaram@stjude.org (RS)

Affiliation Department of Diagnostic Imaging, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

Competing Interests

Dr. Akshay Sharma has received consultant fees from Spotlight Therapeutics, Medexus Inc., Vertex Pharmaceuticals, Sangamo Therapeutics, and Editas Medicine. He has also received research funding from CRISPR Therapeutics and honoraria from Vindico Medical Education. Dr. Sharma is the St. Jude site principal investigator of clinical trials for genome editing for SCD sponsored by Vertex Pharmaceuticals/CRISPR Therapeutics (NCT03745287), Novartis Pharmaceuticals (NCT04443907), and Beam Therapeutics (NCT05456880). The industry sponsors provide funding for the clinical trial, which includes salary support paid to our institution. Dr. Sharma has no direct financial interest in these therapies. Dr. Andrew M. Heitzer has received consulting fees from Global Blood Therapeutics. Neither Dr. Sharma nor Dr. Heitzer is an employee of any commercial entity. All other authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. This does not alter our adherence to PLoS ONE policies on sharing data and materials.