About the Authors

Frances M. Bashore

Contributed equally to this work with: Frances M. Bashore, Vittorio L. Katis, Yuhong Du

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Structural Genomics Consortium, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America

Vittorio L. Katis

Contributed equally to this work with: Frances M. Bashore, Vittorio L. Katis, Yuhong Du

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Visualization, Writing – review & editing

Affiliation Nuffield Department of Medicine, Centre for Medicines Discovery, ARUK Oxford Drug Discovery Institute, University of Oxford, Headington, Oxford, United Kingdom

Yuhong Du

Contributed equally to this work with: Frances M. Bashore, Vittorio L. Katis, Yuhong Du

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Visualization, Writing – review & editing

Affiliations Department of Pharmacology and Chemical Biology, School of Medicine, Emory University, Atlanta, GA, United States of America, Emory Chemical Biology Discovery Center, School of Medicine, Emory University, Atlanta, GA, United States of America

Arunima Sikdar

Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Writing – review & editing

Affiliation Division of Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America

Dongxue Wang

Roles Data curation, Investigation, Methodology, Resources, Validation, Writing – review & editing

Affiliations Department of Pharmacology and Chemical Biology, School of Medicine, Emory University, Atlanta, GA, United States of America, Emory Chemical Biology Discovery Center, School of Medicine, Emory University, Atlanta, GA, United States of America

William J. Bradshaw

Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Writing – review & editing

Affiliation Nuffield Department of Medicine, Centre for Medicines Discovery, ARUK Oxford Drug Discovery Institute, University of Oxford, Headington, Oxford, United Kingdom

Karolina A. Rygiel

Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Writing – review & editing

Affiliation Nuffield Department of Medicine, Centre for Medicines Discovery, ARUK Oxford Drug Discovery Institute, University of Oxford, Headington, Oxford, United Kingdom

Tina M. Leisner

Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Writing – review & editing

Affiliation Division of Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America

Rod Chalk

Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Writing – review & editing

Affiliation Nuffield Department of Medicine, Centre for Medicines Discovery, ARUK Oxford Drug Discovery Institute, University of Oxford, Headington, Oxford, United Kingdom

Swati Mishra

Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Writing – review & editing

Affiliations Department of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Seattle, WA, United States of America, Institute for Stem Cell and Regenerative Medicine, School of Medicine, University of Washington, Seattle, WA, United States of America

C. Andrew Williams

Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Writing – review & editing

Affiliations Department of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Seattle, WA, United States of America, Institute for Stem Cell and Regenerative Medicine, School of Medicine, University of Washington, Seattle, WA, United States of America

Opher Gileadi

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

Current address: Structural Genomics Consortium, Department of Medicine, Karolinska Hospital and Karolinska Institute, Stockholm, Sweden

Affiliation Nuffield Department of Medicine, Centre for Medicines Discovery, ARUK Oxford Drug Discovery Institute, University of Oxford, Headington, Oxford, United Kingdom

Paul E. Brennan

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

Affiliation Nuffield Department of Medicine, Centre for Medicines Discovery, ARUK Oxford Drug Discovery Institute, University of Oxford, Headington, Oxford, United Kingdom

Jesse C. Wiley

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Supervision, Validation, Visualization, Writing – review & editing

Affiliation Sage Bionetworks, Seattle, WA, United States of America

Jake Gockley

Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Writing – review & editing

Affiliation Sage Bionetworks, Seattle, WA, United States of America

Gregory A. Cary

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Visualization, Writing – review & editing

Affiliation The Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME, United States of America

Gregory W. Carter

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

Affiliation The Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME, United States of America

Jessica E. Young

Roles Conceptualization, Supervision, Writing – review & editing

Affiliations Department of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Seattle, WA, United States of America, Institute for Stem Cell and Regenerative Medicine, School of Medicine, University of Washington, Seattle, WA, United States of America

Kenneth H. Pearce

Roles Conceptualization, Supervision, Writing – review & editing

Affiliation Division of Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America

Haian Fu

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

Affiliations Department of Pharmacology and Chemical Biology, School of Medicine, Emory University, Atlanta, GA, United States of America, Emory Chemical Biology Discovery Center, School of Medicine, Emory University, Atlanta, GA, United States of America

the Emory-Sage-SGC TREAT-AD Center

Members of the Emory-Sage-SGC TREAT-AD Center are provided in the Acknowledgments Section.

Alison D. Axtman

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

alison.axtman@unc.edu

Affiliation Structural Genomics Consortium, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America

Competing Interests

The authors have declared that no competing interests exist.