About the Authors

Josh Cone

Roles Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

Affiliation Alexion, AstraZeneca Rare Disease, New Haven, CT, United States of America

Lida Kimmel

Roles Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Alexion Pharmaceuticals, Inc., New Haven, CT, United States of America

Yuchun Zhang

Roles Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

Affiliation Alexion, AstraZeneca Rare Disease, New Haven, CT, United States of America

Krista Johnson

Roles Formal analysis, Supervision, Writing – review & editing

Affiliation Alexion, AstraZeneca Rare Disease, New Haven, CT, United States of America

Douglas Sheridan

Roles Conceptualization, Formal analysis, Writing – review & editing

Affiliation Alexion Pharmaceuticals, Inc., New Haven, CT, United States of America

Paul Tamburini

Roles Conceptualization, Formal analysis, Methodology, Supervision, Visualization, Writing – original draft, Writing – review & editing

paul.tamburini@alexion.com

Affiliation Alexion, AstraZeneca Rare Disease, New Haven, CT, United States of America

Competing Interests

JC, YZ, KJ and PT are employees and shareholders of Alexion, AstraZeneca Rare Disease. PT, KJ and DS are co-inventors on numerous patents and patent applications owned by Alexion, AstraZeneca Rare Disease and/or Alexion Pharmaceuticals, Inc. DS was an employee and shareholder of Alexion Pharmaceuticals, Inc., at the time of study and has received consultancy fees from Alexion, AstraZeneca Rare Disease. DS is now an employee and shareholder of Rallybio. LK was an employee and shareholder of Alexion Pharmaceuticals, Inc., at the time of study. LK is an employee of Arvinas, Inc. and an Arvinas, Inc. shareholder. This does not alter our adherence to PLOS ONE policies on sharing data and materials.