About the Authors

Kieran Patrick

Roles Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom

Xiang Tian

Roles Data curation, Formal analysis, Investigation, Writing – review & editing

Affiliation Dynamic Omics, Centre for Genomics Research, Discovery Sciences, Biopharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, United States of America

David Cartwright

Roles Investigation, Writing – review & editing

Affiliation Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom

Silke Heising

Roles Investigation, Writing – review & editing

Affiliation Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom

Matthew S. Glover

Roles Investigation, Writing – review & editing

Affiliation Dynamic Omics, Centre for Genomics Research, Discovery Sciences, Biopharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, United States of America

Ellie N. Northall

Roles Investigation

Affiliation Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom

Lisa Cazares

Roles Resources, Supervision, Writing – review & editing

Affiliation Dynamic Omics, Centre for Genomics Research, Discovery Sciences, Biopharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, United States of America

Sonja Hess

Roles Resources, Supervision, Writing – review & editing

Affiliation Dynamic Omics, Centre for Genomics Research, Discovery Sciences, Biopharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, United States of America

David Baker

Roles Conceptualization, Resources, Writing – review & editing

Affiliation BioPharmaceuticals R&D, Cardiovascular, Renal and Metabolism (CVRM), Cambridge, United Kingdom

Christopher Church

Roles Conceptualization, Supervision, Writing – review & editing

Affiliation BioPharmaceuticals R&D, Cardiovascular, Renal and Metabolism (CVRM), Cambridge, United Kingdom

Graeme Davies

Roles Conceptualization, Investigation, Supervision, Writing – original draft

Affiliation BioPharmaceuticals R&D, Cardiovascular, Renal and Metabolism (CVRM), Cambridge, United Kingdom

Gareth Lavery

Roles Conceptualization, Resources, Supervision, Writing – review & editing

Affiliation Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom

Amy J. Naylor

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

a.naylor@bham.ac.uk

Affiliation Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom

Competing Interests

I have read the journal’s policy and the authors of this manuscript have the following competing interests: XT, MSG, LC, SH, DB, CC, GD are employees of AstraZeneca and may own stocks and/or restricted stocks. This does not alter our adherence to PLOS ONE policies on sharing data and materials.